Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1171604..1172236 Replicon chromosome
Accession NZ_CP054626
Organism Cupriavidus gilardii strain FDAARGOS_639

Toxin (Protein)


Gene name hicA Uniprot ID A0A0M5KT30
Locus tag FOB47_RS15575 Protein ID WP_053821538.1
Coordinates 1172060..1172236 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FOB47_RS15570 Protein ID WP_174781486.1
Coordinates 1171604..1172020 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB47_RS15555 1167066..1167593 + 528 WP_006576455.1 peptidylprolyl isomerase -
FOB47_RS15560 1167669..1168748 - 1080 WP_174781485.1 hypothetical protein -
FOB47_RS15565 1168745..1171501 - 2757 WP_170265930.1 DNA mismatch repair protein MutS -
FOB47_RS15570 1171604..1172020 - 417 WP_174781486.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FOB47_RS15575 1172060..1172236 - 177 WP_053821538.1 type II toxin-antitoxin system HicA family toxin Toxin
FOB47_RS15580 1172403..1173221 - 819 WP_064573223.1 inositol monophosphatase -
FOB47_RS15585 1173418..1174326 + 909 WP_174781487.1 RNA methyltransferase -
FOB47_RS15590 1174687..1175430 + 744 WP_006577564.1 serine O-acetyltransferase -
FOB47_RS15595 1175481..1176263 - 783 WP_053821541.1 UDP-2,3-diacylglucosamine diphosphatase -
FOB47_RS15600 1176380..1176880 - 501 WP_023264649.1 peptidyl-prolyl cis-trans isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6588.65 Da        Isoelectric Point: 11.9145

>T159993 WP_053821538.1 NZ_CP054626:c1172236-1172060 [Cupriavidus gilardii]
VKQSEFRRWLGRQGATFADGGKHLKVYLNGRQSTMPRHPGKEIAERTRKAILKQLGLA

Download         Length: 177 bp

>T159993 NZ_CP070232:189519-189626 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15377.58 Da        Isoelectric Point: 4.3708

>AT159993 WP_174781486.1 NZ_CP054626:c1172020-1171604 [Cupriavidus gilardii]
MLRYPVILTADDDGVAVSFPDIPEALTCGDSHEEALQMATDALVTAMDFYFEDRRPVPMPSAPEVGQELVDLPASLSAKV
LLLNEMLSQKVSQSELARRLDTRPQEVQRIVNLDHTTKIDTIEAAFRALGRRIELRIT

Download         Length: 417 bp

>AT159993 NZ_CP070232:c189471-189405 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5KT30

Antitoxin

Source ID Structure

References