Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1295858..1296462 Replicon chromosome
Accession NZ_CP054624
Organism Cupriavidus gilardii strain FDAARGOS_639

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag FOB47_RS05990 Protein ID WP_174780282.1
Coordinates 1295858..1296163 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag FOB47_RS05995 Protein ID WP_082371731.1
Coordinates 1296160..1296462 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOB47_RS05975 1291337..1293748 + 2412 WP_174780280.1 S8 family serine peptidase -
FOB47_RS05980 1293764..1294159 - 396 WP_174780281.1 DUF1311 domain-containing protein -
FOB47_RS05985 1294420..1295613 + 1194 WP_053823865.1 MFS transporter -
FOB47_RS05990 1295858..1296163 + 306 WP_174780282.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOB47_RS05995 1296160..1296462 + 303 WP_082371731.1 putative addiction module antidote protein Antitoxin
FOB47_RS06000 1296494..1297822 - 1329 WP_174780283.1 MFS transporter -
FOB47_RS06005 1297930..1298688 - 759 WP_174780284.1 glucose 1-dehydrogenase -
FOB47_RS06010 1298811..1299182 - 372 WP_053823862.1 cupin domain-containing protein -
FOB47_RS06015 1299242..1299985 - 744 WP_053823861.1 GntR family transcriptional regulator -
FOB47_RS06020 1300224..1301201 + 978 WP_053823860.1 tripartite tricarboxylate transporter substrate binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(7-94)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11285.06 Da        Isoelectric Point: 10.7461

>T159991 WP_174780282.1 NZ_CP054624:1295858-1296163 [Cupriavidus gilardii]
MIEIREYPPFRRWLSGLPDEATKAVIARRLMRLSVGNFGDAKSVGGGVSELRIDYGPGFRVYFAREGPRVVLLLGGGDKS
TQHLDIRKAQALWAEIKRTQA

Download         Length: 306 bp

>T159991 NZ_CP070231:c32890-32642 [Escherichia coli]
ATGGGGAAAGCAGATAAGCTACTGGCAAAATTTTTAAACAGTAAAAAAACGTTTGAATGGGATGAACTCGTTGTTTTGTT
TTCTTCTCTAGGATATGTCAAAAAGGAAATGCAGGGATCAAGAGTGCGATTTTTCAATGCTGAAATTAATCACACAATAT
TAATGCATCGCCCACATCCAGAAAGTTATATTAAAGGTGGAACGCTGAAAGCTATTAAACAGAACTTGAAAGAGGCTGGG
GTTTTATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10773.23 Da        Isoelectric Point: 4.6290

>AT159991 WP_082371731.1 NZ_CP054624:1296160-1296462 [Cupriavidus gilardii]
MKDLEYRTFDPARYLDTDEARAAFLADALMDADHPELFAEALAAVARSRGNIAETAQAAGLSTSGLYKILGADSDPKLST
LRALLDVLGVELTIRPKLAH

Download         Length: 303 bp

>AT159991 NZ_CP070231:c32645-32298 [Escherichia coli]
ATGAAACATTTAAAATATAAAGGATATTTAGGTACGGTTGAGCCGGATTTTGAAAATAATATCCTGTATGGAAAGCTGGC
ATTTATTCGTGATCTGGTGACTTATGAGGCAGAAACATTGGCTGACCTGGAACGGGAATTTAAAACATCGGTTGATTTGT
ATTTACAGTCCTGTGTGGAGGACGGAAAGGAGCCTGACACGCCCTTTAAAGGTGTGTTTAACGTCAGGCTTGATCCAGAG
CTGCATCGTCGGGTCGCTGAAATGGCGATGGAAGAAGATTTGTCGCTGAATGCCTTTGTCAATAAGGCACTGGAAAAAGA
AGTCAGTCATCATCGCGCAGGGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References