Detailed information of TA system TA159989

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4632485..4633743
• Replicon: chromosome
• Accession: NZ_CP054623
• Organism: Pseudomonas aeruginosa strain DL201330

Toxin (Protein)

• Gene name: -
• Uniprot ID: V6AJ34
• Locus tag: HUF09_RS21775
• Protein ID: WP_003086331.1
• Coordinates: 4632485..4633240 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: HUF09_RS21780
• Protein ID: WP_003086329.1
• Coordinates: 4633375..4633743 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUF09_RS21765	4627656..4630199	+	2544	WP_033979231.1	acyl-homoserine-lactone acylase QuiP	-
HUF09_RS21770	4630355..4631716	-	1362	WP_003120632.1	DNA recombination protein RmuC	-
HUF09_RS21775	4632485..4633240	-	756	WP_003086331.1	RES family NAD+ phosphorylase	Toxin
HUF09_RS21780	4633375..4633743	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
HUF09_RS21785	4633816..4635102	-	1287	WP_003086327.1	FAD-binding oxidoreductase	-
HUF09_RS21790	4635158..4636747	-	1590	WP_023464367.1	aldehyde dehydrogenase family protein	-
HUF09_RS21795	4636826..4637302	+	477	WP_004353334.1	elongation factor GreAB	-
HUF09_RS21800	4637305..4637580	-	276	WP_023088486.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28236.34 Da
• Isoelectric Point: 7.7294

>T159989 WP_003086331.1 NZ_CP054623:c4633240-4632485 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T159989 NZ_CP070230:c49867-49379 [Escherichia coli]
ATGGGAGGTGTAACAGCACCAGAACCTTTGTCCTCATTTCATCAGGCCGCTGAATTTGTCAGTGGTGAAGCTGTGCTTGA
TGACTGGTTAAAGCAGAAGGGGCTGAAAAATCAGGCTCTCGGAGCCACACGGACTTTTGTTGTATGCAGAAAAGGTTCGC
AACAAATAGTCGGTTTTTACTCTCTGGCCACCGGGAGTGTTAATCATACAGAGGCTGCAGGCAACCTTCGGCGCAATATG
CCAGACCCTATACCTGTTATTATACTTGCACGCCTGGCCGTTGATGTGTCATTCCGTGGAAAAGGGCTTGGCGCAGATTT
ACTTCATGATGCTGTTTGTCGTTGTTACAGGGTTGCCGAAAATATCGGTGTGCGTGCAATTATGGTTCATGCGCTTACGG
AAAACGCAAAACAGTTTTATATTCATCATGGTTTTAAGCCATCAAAAAGCCAGGAGCAAACATTGTTTCTTAAACTCCCC
GGCAAGTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT159989 WP_003086329.1 NZ_CP054623:c4633743-4633375 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT159989 NZ_CP070230:c50139-49855 [Escherichia coli]
ATGATATACGGAGGCTTTATGAAATCAGGTGTTCAGCTCAATCTCAGGGCAAGAGAATCTCAGCGGATACTCATTGATAC
CGCTGCAGAAATTCTTCATAAGTCGCGTACAGACTTCATTCTGGAAATGGCCTGTAAAGCTGCTGAAGATATTATTCTTG
ACCGGCGGGTGTTTAATTTTAATGACAGGCAATATGAAGAGTTCATCGAAATGCTTGATGCTCCGGTTGCTGATGAGACT
GCCATCGAAAAACTGCTGGCGAGGAAACCTCAATGGGAGGTGTAA

Structures

Toxin

• AlphaFold DB: V6AJ34

Antitoxin

• AlphaFold DB: V6AJU7