Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 160197..160702 Replicon chromosome
Accession NZ_CP054623
Organism Pseudomonas aeruginosa strain DL201330

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag HUF09_RS00765 Protein ID WP_003083773.1
Coordinates 160197..160478 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag HUF09_RS00770 Protein ID WP_003083775.1
Coordinates 160475..160702 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUF09_RS00740 155448..156797 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
HUF09_RS00745 156846..157532 + 687 WP_003083762.1 FadR family transcriptional regulator -
HUF09_RS00750 157633..158367 + 735 WP_004346926.1 GntR family transcriptional regulator -
HUF09_RS00755 158571..158957 + 387 WP_014602345.1 aegerolysin family protein -
HUF09_RS00760 158989..159897 - 909 WP_003083769.1 LysR family transcriptional regulator -
HUF09_RS00765 160197..160478 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
HUF09_RS00770 160475..160702 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
HUF09_RS00775 160878..161498 - 621 WP_003101226.1 hypothetical protein -
HUF09_RS00780 161599..162099 + 501 WP_003101228.1 LEA type 2 family protein -
HUF09_RS00785 162172..162513 + 342 WP_003101229.1 alkylphosphonate utilization protein -
HUF09_RS00790 162595..164022 - 1428 WP_003083784.1 GABA permease -
HUF09_RS00795 164191..165684 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T159984 WP_003083773.1 NZ_CP054623:c160478-160197 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T159984 NZ_CP070229:4031283-4031618 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGGGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT159984 WP_003083775.1 NZ_CP054623:c160702-160475 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT159984 NZ_CP070229:4031035-4031283 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References