Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 66768..67329 Replicon plasmid unnamed9
Accession NZ_CP054608
Organism Sulfitobacter pseudonitzschiae strain H46

Toxin (Protein)


Gene name relE Uniprot ID A0A073IX00
Locus tag HT745_RS24125 Protein ID WP_037930052.1
Coordinates 67054..67329 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A073IXE5
Locus tag HT745_RS24120 Protein ID WP_037930055.1
Coordinates 66768..67061 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HT745_RS24105 62246..63781 - 1536 WP_037930157.1 aldehyde dehydrogenase (NADP(+)) -
HT745_RS24110 64042..65781 + 1740 WP_037930061.1 dihydroxy-acid dehydratase -
HT745_RS24115 65792..66697 + 906 WP_037930058.1 dihydrodipicolinate synthase family protein -
HT745_RS24120 66768..67061 + 294 WP_037930055.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HT745_RS24125 67054..67329 + 276 WP_037930052.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HT745_RS24130 67800..68501 - 702 WP_081855460.1 GntR family transcriptional regulator -
HT745_RS24135 68662..70209 + 1548 WP_037930049.1 altronate dehydratase family protein -
HT745_RS24140 70226..71542 + 1317 WP_037930047.1 DUF2088 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..79728 79728


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-54)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10080.66 Da        Isoelectric Point: 4.7027

>T159974 WP_037930052.1 NZ_CP054608:67054-67329 [Sulfitobacter pseudonitzschiae]
VPDLEWKALAVADLMAIVDYISDDNPDAAISLMDDIQDKVLGLLTHPKSGRPGRVNDTRELVIRPKYIVVYAENTAAVTV
LRVLHAAQMWP

Download         Length: 276 bp

>T159974 NZ_CP070229:c2075274-2074960 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGACTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10140.55 Da        Isoelectric Point: 7.2024

>AT159974 WP_037930055.1 NZ_CP054608:66768-67061 [Sulfitobacter pseudonitzschiae]
MSAQTSMIHVRVDDQLKAKATDALSGVGLTLSDAVRILLTRVAAEGGLPAGLTANADAYDAWFRAKVQDALADAAPAKPH
DQVMRDARALIDGKRGA

Download         Length: 294 bp

>AT159974 NZ_CP070229:c2075510-2075277 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A073IX00

Antitoxin

Source ID Structure
AlphaFold DB A0A073IXE5

References