Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 93413..94065 Replicon plasmid unnamed4
Accession NZ_CP054603
Organism Sulfitobacter pseudonitzschiae strain H46

Toxin (Protein)


Gene name vapC Uniprot ID A0A073IX31
Locus tag HT745_RS20720 Protein ID WP_037930703.1
Coordinates 93413..93823 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A073IXF8
Locus tag HT745_RS20725 Protein ID WP_037930707.1
Coordinates 93823..94065 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HT745_RS20705 90066..91142 - 1077 WP_174861782.1 tricarboxylate transporter -
HT745_RS20710 91291..91962 + 672 WP_037930753.1 response regulator transcription factor -
HT745_RS20715 91952..93349 + 1398 WP_051694657.1 sensor histidine kinase -
HT745_RS20720 93413..93823 - 411 WP_037930703.1 type II toxin-antitoxin system VapC family toxin Toxin
HT745_RS20725 93823..94065 - 243 WP_037930707.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HT745_RS20730 94214..94828 - 615 WP_037930714.1 SMC-Scp complex subunit ScpB -
HT745_RS20735 94831..95715 - 885 WP_037930718.1 DUF1403 family protein -
HT745_RS20740 96432..97022 - 591 WP_037930722.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..164359 164359


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-48)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15223.37 Da        Isoelectric Point: 5.2132

>T159972 WP_037930703.1 NZ_CP054603:c93823-93413 [Sulfitobacter pseudonitzschiae]
MYILDTNVISAVRRPDRAPKVEAWLRGKPEQDLFLSVITLGEIERGIRQQETRDPDFAHDLRVWLDRTVTLFSDRLLSFD
AEDARIWGQLSVKIGHAGADLMIAATGLRHGAVIVTGNVRDFALTGVSIENPFEPV

Download         Length: 411 bp

>T159972 NZ_CP070229:c1622113-1621811 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8895.09 Da        Isoelectric Point: 6.4623

>AT159972 WP_037930707.1 NZ_CP054603:c94065-93823 [Sulfitobacter pseudonitzschiae]
MWTLQDAKNKFSAVVDAALAGTPQEVTRRGKPAVVILSAEEYHRLVESAVQRRESFADHLMAFPGEDIPRAQAALRDVNF

Download         Length: 243 bp

>AT159972 NZ_CP070229:c1621775-1621434 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTACTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAATAATCGTAAACTCACCACTG
AAATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A073IX31

Antitoxin

Source ID Structure
AlphaFold DB A0A073IXF8

References