Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 545041..545506 Replicon chromosome
Accession NZ_CP054599
Organism Sulfitobacter pseudonitzschiae strain H46

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag HT745_RS02670 Protein ID WP_174861618.1
Coordinates 545243..545506 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A073IVW0
Locus tag HT745_RS02665 Protein ID WP_037931637.1
Coordinates 545041..545256 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HT745_RS02650 540252..541091 + 840 WP_174861615.1 DUF3800 domain-containing protein -
HT745_RS02655 541088..544297 + 3210 WP_174861616.1 HsdR family type I site-specific deoxyribonuclease -
HT745_RS02660 544294..545010 + 717 WP_174861617.1 M48 family metallopeptidase -
HT745_RS02665 545041..545256 - 216 WP_037931637.1 hypothetical protein Antitoxin
HT745_RS02670 545243..545506 - 264 WP_174861618.1 BrnT family toxin Toxin
HT745_RS02675 545587..545838 - 252 WP_174861619.1 WGR domain-containing protein -
HT745_RS02680 545844..546383 - 540 WP_174861753.1 tyrosine-type recombinase/integrase -
HT745_RS02685 546737..547150 - 414 WP_153218054.1 helix-turn-helix domain-containing protein -
HT745_RS02690 547227..547634 + 408 WP_007803565.1 mercury transporter -
HT745_RS02695 547650..547952 + 303 WP_040545980.1 hypothetical protein -
HT745_RS02700 547983..548234 + 252 WP_072629817.1 hypothetical protein -
HT745_RS02705 548231..548617 + 387 WP_007803570.1 mercury resistance system transport protein MerF -
HT745_RS02710 548614..548751 + 138 WP_007803572.1 hypothetical protein -
HT745_RS02715 548735..550183 + 1449 WP_082631153.1 mercury(II) reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 381374..558447 177073


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-80)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10157.26 Da        Isoelectric Point: 5.1298

>T159969 WP_174861618.1 NZ_CP054599:c545506-545243 [Sulfitobacter pseudonitzschiae]
MKFEYDPDKSAANREKHGIDFDEAQALWNDPYLIEAPANVTDEPRFLAVGMIGARHWTAVYTYRSDRVRIISVRRARTQE
IDHYEGD

Download         Length: 264 bp

>T159969 NZ_CP070229:808007-808114 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8274.49 Da        Isoelectric Point: 7.0141

>AT159969 WP_037931637.1 NZ_CP054599:c545256-545041 [Sulfitobacter pseudonitzschiae]
MKATEFDERFEAGEDMSAHVDWTKARRLNVEAKRVNVDFPTWVVAGLDRQAQKLGITRQALIKMWIAERLE

Download         Length: 216 bp

>AT159969 NZ_CP070229:c807954-807893 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A073IVW0

References