Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 2418140..2418723 Replicon chromosome
Accession NZ_CP054596
Organism Bifidobacterium longum subsp. infantis strain PI_006

Toxin (Protein)


Gene name PumA Uniprot ID A0A1S2VZ23
Locus tag HUE65_RS10735 Protein ID WP_032745284.1
Coordinates 2418140..2418442 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID I3AVV5
Locus tag HUE65_RS10740 Protein ID WP_007057517.1
Coordinates 2418439..2418723 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUE65_RS10720 (HUE65_10730) 2413879..2416998 - 3120 WP_136527129.1 alpha-mannosidase -
HUE65_RS10725 (HUE65_10735) 2417159..2417647 - 489 WP_032745281.1 D-aminoacyl-tRNA deacylase -
HUE65_RS10730 (HUE65_10740) 2417773..2418102 + 330 WP_257798116.1 DUF1922 domain-containing protein -
HUE65_RS10735 (HUE65_10745) 2418140..2418442 + 303 WP_032745284.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUE65_RS10740 (HUE65_10750) 2418439..2418723 + 285 WP_007057517.1 putative addiction module antidote protein Antitoxin
HUE65_RS10745 (HUE65_10755) 2418832..2419383 + 552 Protein_2092 IS30 family transposase -
HUE65_RS10750 (HUE65_10760) 2419401..2420132 - 732 WP_032744305.1 ABC transporter permease -
HUE65_RS10755 (HUE65_10765) 2420129..2421037 - 909 WP_032744304.1 ABC transporter ATP-binding protein -
HUE65_RS10760 (HUE65_10770) 2421135..2422217 - 1083 Protein_2095 transposase -
HUE65_RS10765 (HUE65_10775) 2422211..2422579 + 369 WP_155270629.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2418928..2419383 455


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(9-92)

Antitoxin

Uncharacterized protein HI1420

(3-92)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11350.08 Da        Isoelectric Point: 10.4626

>T159968 WP_032745284.1 NZ_CP054596:2418140-2418442 [Bifidobacterium longum subsp. infantis]
IKQSAEYRKWFKKLRDHKAKAAIQARLDACKLAGRPFGDIKPVGGPVSEMRFHTGAGYRVYFAMQGNVLMLLLAGGDKST
QQTDIRQAHDILNDYKEQRQ

Download         Length: 303 bp

>T159968 NZ_CP070229:582759-583037 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10158.37 Da        Isoelectric Point: 4.3707

>AT159968 WP_007057517.1 NZ_CP054596:2418439-2418723 [Bifidobacterium longum subsp. infantis]
MSTEFTDYDTSEYLENEQDIIAYLNAIAEYDDPALMQAALGNVAKARGMTQIAKDAGVGRESLYKSLSKDGNPSFQTIAK
VIHALGGRLTIQAA

Download         Length: 285 bp

>AT159968 NZ_CP070229:583037-583321 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S2VZ23

Antitoxin

Source ID Structure
AlphaFold DB I3AVV5

References