Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-RelB
Location 1870399..1870948 Replicon chromosome
Accession NZ_CP054596
Organism Bifidobacterium longum subsp. infantis strain PI_006

Toxin (Protein)


Gene name mazF Uniprot ID S2ZXD7
Locus tag HUE65_RS08085 Protein ID WP_003829109.1
Coordinates 1870399..1870722 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0M4LW25
Locus tag HUE65_RS08090 Protein ID WP_032743660.1
Coordinates 1870709..1870948 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUE65_RS08060 (HUE65_08070) 1865892..1866181 - 290 Protein_1560 IS256 family transposase -
HUE65_RS08065 (HUE65_08075) 1866651..1867916 - 1266 WP_050496214.1 Fic family protein -
HUE65_RS08070 (HUE65_08080) 1868458..1868823 - 366 WP_032743659.1 YccF domain-containing protein -
HUE65_RS08075 (HUE65_08085) 1869061..1869420 + 360 WP_080714682.1 class I SAM-dependent methyltransferase -
HUE65_RS08080 (HUE65_08090) 1869568..1870182 + 615 WP_080714683.1 cupin domain-containing protein -
HUE65_RS08085 (HUE65_08095) 1870399..1870722 - 324 WP_003829109.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HUE65_RS08090 (HUE65_08100) 1870709..1870948 - 240 WP_032743660.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUE65_RS08095 (HUE65_08105) 1871128..1872384 + 1257 WP_032743661.1 HipA domain-containing protein -
HUE65_RS08100 1872720..1872830 + 111 WP_230581173.1 XRE family transcriptional regulator -
HUE65_RS08105 (HUE65_08115) 1873014..1874285 - 1272 WP_032743663.1 MFS transporter -
HUE65_RS08110 (HUE65_08120) 1874442..1875104 - 663 WP_032743761.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-103)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-54)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11859.67 Da        Isoelectric Point: 5.0771

>T159965 WP_003829109.1 NZ_CP054596:c1870722-1870399 [Bifidobacterium longum subsp. infantis]
MKRGEIWTLQADGYASKPRPVVIVQSDAVDRFDSVITCLLTSYDSSDIDTRVRLEPSPENGLNKVSYVMTDKIVTVDRKL
LGYQVGVVDDAAMANIGRQLMRVLGLL

Download         Length: 324 bp

>T159965 NZ_CP070228:c1685234-1684977 [Arcanobacterium phocisimile]
ATGAAAACTATGTCATATTCTGAATCGCGTGCGAACTATGCAGATGTTCTGAAATCGGTTGTTGAAGATCGAGAAGAAGT
CATCATTACCCGCAAAGGTCACGATTCTGCAGTGATTGTTTCGCTCGATGACTATAATTCGCTGCGAGAAACCGCGTATT
TGATGCGGTCACCGCGCAATGCGCGCAGGCTATTTGATGCTGTCGATCGATTAGAAGCGGGAGAAGGTACAGTTCAGCCA
CTCCTCGAAGCGGAGTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9121.16 Da        Isoelectric Point: 4.5881

>AT159965 WP_032743660.1 NZ_CP054596:c1870948-1870709 [Bifidobacterium longum subsp. infantis]
MQIATRVDDEQAALFKETTRQLGTTPADALRMFISAFNDYRGFPYEVRLPRNDVEPFASERDATEYASRLALRMSDETR

Download         Length: 240 bp

>AT159965 NZ_CP070228:c1684971-1684717 [Arcanobacterium phocisimile]
GTGAAATATGTCTGGGATGAGAACGCCTGGCAAGACTACCTATGGTGGCAAGCCCACGACCGGAAGATGCTGAAGCGAAT
CAACCTCTTGCTTAAAGATATTTCGCGCAACGGAAACGAAGGTATCGGGAAGCCGGAACCATTGAAATATGAGCTTGCCG
GATATTGGTCGCGCAGGATCTCTGATGAACATCGCCTCGTTTATAAATACACCGAAACGGCAGTATATATAGCTGCTTGC
AGATACCACTATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A087B6Q7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M4LW25

References