Detailed information of TA system TA159964

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 1475179..1475668
• Replicon: chromosome
• Accession: NZ_CP054596
• Organism: Bifidobacterium longum subsp. infantis strain PI_006

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HUE65_RS06385
• Protein ID: WP_229773994.1
• Coordinates: 1475441..1475668 (+)
• Length: 76 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A4V2N072
• Locus tag: HUE65_RS06380
• Protein ID: WP_032744823.1
• Coordinates: 1475179..1475415 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUE65_RS06365 (HUE65_06380)	1471333..1472520	+	1188	WP_032744825.1	carboxylate--amine ligase	-
HUE65_RS06370 (HUE65_06385)	1472547..1473872	+	1326	WP_230581269.1	MFS transporter	-
HUE65_RS06375 (HUE65_06390)	1473883..1474596	+	714	WP_080714860.1	4'-phosphopantetheinyl transferase superfamily protein	-
HUE65_RS06380 (HUE65_06395)	1475179..1475415	+	237	WP_032744823.1	ribbon-helix-helix domain-containing protein	Antitoxin
HUE65_RS06385 (HUE65_06400)	1475441..1475668	+	228	WP_229773994.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HUE65_RS06390 (HUE65_06405)	1476019..1476681	-	663	WP_136527151.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
HUE65_RS06395 (HUE65_06410)	1476702..1477658	+	957	WP_032744820.1	A/G-specific adenine glycosylase	-
HUE65_RS06400 (HUE65_06415)	1477723..1478445	+	723	WP_032744819.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1467069..1475668	8599

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-72)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 8653.22 Da
• Isoelectric Point: 10.1818

>T159964 WP_229773994.1 NZ_CP054596:1475441-1475668 [Bifidobacterium longum subsp. infantis]
MKKLDRNVAKRIIAKLREISQLEDPRSTGKALAGNLAGLWRYRVGDYRIVCDIEDEVLLILVIDVAHRSKVYKRC

Nucleotide

• Length: 228 bp

>T159964 NZ_CP070228:c1684971-1684717 [Arcanobacterium phocisimile]
GTGAAATATGTCTGGGATGAGAACGCCTGGCAAGACTACCTATGGTGGCAAGCCCACGACCGGAAGATGCTGAAGCGAAT
CAACCTCTTGCTTAAAGATATTTCGCGCAACGGAAACGAAGGTATCGGGAAGCCGGAACCATTGAAATATGAGCTTGCCG
GATATTGGTCGCGCAGGATCTCTGATGAACATCGCCTCGTTTATAAATACACCGAAACGGCAGTATATATAGCTGCTTGC
AGATACCACTATTAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8928.15 Da
• Isoelectric Point: 4.2821

>AT159964 WP_032744823.1 NZ_CP054596:1475179-1475415 [Bifidobacterium longum subsp. infantis]
MATVTAALRMPVELAARYDCLAKATGRTKTFYMNEALTESIDRFEYEYGIMKKVEDWRAGRLETVTLDELEESLGLED

Nucleotide

• Length: 237 bp

>AT159964 NZ_CP070228:c1685234-1684977 [Arcanobacterium phocisimile]
ATGAAAACTATGTCATATTCTGAATCGCGTGCGAACTATGCAGATGTTCTGAAATCGGTTGTTGAAGATCGAGAAGAAGT
CATCATTACCCGCAAAGGTCACGATTCTGCAGTGATTGTTTCGCTCGATGACTATAATTCGCTGCGAGAAACCGCGTATT
TGATGCGGTCACCGCGCAATGCGCGCAGGCTATTTGATGCTGTCGATCGATTAGAAGCGGGAGAAGGTACAGTTCAGCCA
CTCCTCGAAGCGGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A4V2N072