Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 832206..832771 Replicon chromosome
Accession NZ_CP054596
Organism Bifidobacterium longum subsp. infantis strain PI_006

Toxin (Protein)


Gene name relE Uniprot ID A0A0M4LG91
Locus tag HUE65_RS03755 Protein ID WP_060620320.1
Coordinates 832481..832771 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7D5CUA8
Locus tag HUE65_RS03750 Protein ID WP_032743427.1
Coordinates 832206..832484 (+) Length 93 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUE65_RS03720 (HUE65_03730) 827409..828671 + 1263 WP_032743422.1 metallophosphoesterase -
HUE65_RS03735 (HUE65_03745) 830146..830337 + 192 WP_032743423.1 hypothetical protein -
HUE65_RS03740 (HUE65_03750) 830759..831403 - 645 WP_032743426.1 hypothetical protein -
HUE65_RS03745 (HUE65_03755) 831617..831733 + 117 Protein_725 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
HUE65_RS03750 (HUE65_03760) 832206..832484 + 279 WP_032743427.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUE65_RS03755 (HUE65_03765) 832481..832771 + 291 WP_060620320.1 type II toxin-antitoxin system YafQ family toxin Toxin
HUE65_RS03760 (HUE65_03770) 833149..834495 + 1347 WP_032743429.1 NADP-specific glutamate dehydrogenase -
HUE65_RS03765 (HUE65_03775) 834644..834868 + 225 WP_032743431.1 substrate-binding domain-containing protein -
HUE65_RS03770 (HUE65_03780) 834929..836350 - 1422 WP_032743432.1 ATP-binding protein -
HUE65_RS03775 (HUE65_03785) 836996..837562 - 567 WP_032743433.1 DUF3566 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 822301..836350 14049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-95)

Antitoxin

(6-70)


Sequences


Toxin        


Download         Length: 97 a.a.        Molecular weight: 10839.54 Da        Isoelectric Point: 9.9591

>T159963 WP_060620320.1 NZ_CP054596:832481-832771 [Bifidobacterium longum subsp. infantis]
MSGIQYTVKTTSRFRKDFKLARRRGLDAGLFKQVVSILSEGGTLPDRYHDHALTGNMTGFRECHITPDLLLVYLIEKDVL
VLTLTRTGTHSDLFGK

Download         Length: 291 bp

>T159963 NZ_CP070227:c4809639-4809532 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10274.69 Da        Isoelectric Point: 5.1231

>AT159963 WP_032743427.1 NZ_CP054596:832206-832484 [Bifidobacterium longum subsp. infantis]
MSGTTTTVNVRMNAELKKQAEELFEELGMNLTTAVNIFIRQSLRQGGIPFNVSLDEPNRETVSAMLEAKRIARDGNVKGY
RDLNALFKDLDA

Download         Length: 279 bp

>AT159963 NZ_CP070227:4809696-4809751 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0M4LG91


Antitoxin

Source ID Structure
AlphaFold DB A0A7D5CUA8

References