Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/YafQ-DinJ |
Location | 832206..832771 | Replicon | chromosome |
Accession | NZ_CP054596 | ||
Organism | Bifidobacterium longum subsp. infantis strain PI_006 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A0M4LG91 |
Locus tag | HUE65_RS03755 | Protein ID | WP_060620320.1 |
Coordinates | 832481..832771 (+) | Length | 97 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A7D5CUA8 |
Locus tag | HUE65_RS03750 | Protein ID | WP_032743427.1 |
Coordinates | 832206..832484 (+) | Length | 93 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HUE65_RS03720 (HUE65_03730) | 827409..828671 | + | 1263 | WP_032743422.1 | metallophosphoesterase | - |
HUE65_RS03735 (HUE65_03745) | 830146..830337 | + | 192 | WP_032743423.1 | hypothetical protein | - |
HUE65_RS03740 (HUE65_03750) | 830759..831403 | - | 645 | WP_032743426.1 | hypothetical protein | - |
HUE65_RS03745 (HUE65_03755) | 831617..831733 | + | 117 | Protein_725 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
HUE65_RS03750 (HUE65_03760) | 832206..832484 | + | 279 | WP_032743427.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
HUE65_RS03755 (HUE65_03765) | 832481..832771 | + | 291 | WP_060620320.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
HUE65_RS03760 (HUE65_03770) | 833149..834495 | + | 1347 | WP_032743429.1 | NADP-specific glutamate dehydrogenase | - |
HUE65_RS03765 (HUE65_03775) | 834644..834868 | + | 225 | WP_032743431.1 | substrate-binding domain-containing protein | - |
HUE65_RS03770 (HUE65_03780) | 834929..836350 | - | 1422 | WP_032743432.1 | ATP-binding protein | - |
HUE65_RS03775 (HUE65_03785) | 836996..837562 | - | 567 | WP_032743433.1 | DUF3566 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 822301..836350 | 14049 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 10839.54 Da Isoelectric Point: 9.9591
>T159963 WP_060620320.1 NZ_CP054596:832481-832771 [Bifidobacterium longum subsp. infantis]
MSGIQYTVKTTSRFRKDFKLARRRGLDAGLFKQVVSILSEGGTLPDRYHDHALTGNMTGFRECHITPDLLLVYLIEKDVL
VLTLTRTGTHSDLFGK
MSGIQYTVKTTSRFRKDFKLARRRGLDAGLFKQVVSILSEGGTLPDRYHDHALTGNMTGFRECHITPDLLLVYLIEKDVL
VLTLTRTGTHSDLFGK
Download Length: 291 bp
>T159963 NZ_CP070227:c4809639-4809532 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10274.69 Da Isoelectric Point: 5.1231
>AT159963 WP_032743427.1 NZ_CP054596:832206-832484 [Bifidobacterium longum subsp. infantis]
MSGTTTTVNVRMNAELKKQAEELFEELGMNLTTAVNIFIRQSLRQGGIPFNVSLDEPNRETVSAMLEAKRIARDGNVKGY
RDLNALFKDLDA
MSGTTTTVNVRMNAELKKQAEELFEELGMNLTTAVNIFIRQSLRQGGIPFNVSLDEPNRETVSAMLEAKRIARDGNVKGY
RDLNALFKDLDA
Download Length: 279 bp
>AT159963 NZ_CP070227:4809696-4809751 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0M4LG91 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7D5CUA8 |