159960

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2764308..2765529 Replicon chromosome
Accession NZ_CP054591
Organism Pseudomonas aeruginosa strain CDN118

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HR116_RS12875 Protein ID WP_003114949.1
Coordinates 2764308..2764886 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HR116_RS12880 Protein ID WP_019371885.1
Coordinates 2764975..2765529 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HR116_RS12860 2759585..2760862 + 1278 WP_003102743.1 TolC family protein -
HR116_RS12865 2760852..2763023 + 2172 WP_003114950.1 type I secretion system permease/ATPase -
HR116_RS12870 2763013..2764200 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
HR116_RS12875 2764308..2764886 - 579 WP_003114949.1 HD domain-containing protein Toxin
HR116_RS12880 2764975..2765529 - 555 WP_019371885.1 helix-turn-helix domain-containing protein Antitoxin
HR116_RS12885 2765687..2767882 - 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
HR116_RS12890 2767887..2768348 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
HR116_RS12895 2768679..2769002 + 324 WP_003102734.1 multidrug efflux SMR transporter -
HR116_RS12900 2769015..2769413 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
HR116_RS12905 2769410..2769961 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T159960 WP_003114949.1 NZ_CP054591:c2764886-2764308 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T159960 NZ_CP070227:c3997367-3996960 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20440.60 Da        Isoelectric Point: 8.1590

>AT159960 WP_019371885.1 NZ_CP054591:c2765529-2764975 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLDELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT159960 NZ_CP070227:c3997614-3997348 [Escherichia coli]
ATGGACATTAATAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References