159957

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142619..143124 Replicon chromosome
Accession NZ_CP054591
Organism Pseudomonas aeruginosa strain CDN118

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag HR116_RS00655 Protein ID WP_003083773.1
Coordinates 142619..142900 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag HR116_RS00660 Protein ID WP_003083775.1
Coordinates 142897..143124 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HR116_RS00630 137870..139219 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
HR116_RS00635 139268..139954 + 687 WP_003083762.1 FadR family transcriptional regulator -
HR116_RS00640 140055..140789 + 735 WP_003117208.1 GntR family transcriptional regulator -
HR116_RS00645 140993..141379 + 387 WP_003083767.1 aegerolysin family protein -
HR116_RS00650 141411..142319 - 909 WP_003083769.1 LysR family transcriptional regulator -
HR116_RS00655 142619..142900 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
HR116_RS00660 142897..143124 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
HR116_RS00665 143299..143919 - 621 WP_003101226.1 hypothetical protein -
HR116_RS00670 144020..144520 + 501 WP_003162763.1 LEA type 2 family protein -
HR116_RS00675 144593..144934 + 342 WP_003101229.1 alkylphosphonate utilization protein -
HR116_RS00680 145016..146443 - 1428 WP_003083784.1 GABA permease -
HR116_RS00685 146612..148105 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T159957 WP_003083773.1 NZ_CP054591:c142900-142619 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T159957 NZ_CP070227:c3077173-3076919 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT159957 WP_003083775.1 NZ_CP054591:c143124-142897 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT159957 NZ_CP070227:c3077421-3077170 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References