159946

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1389991..1390907 Replicon chromosome
Accession NZ_CP054584
Organism Bacillus halotolerans strain KKD1

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A7G7U9Y2
Locus tag HT135_RS07180 Protein ID WP_024121091.1
Coordinates 1390161..1390907 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A7G7U9Y3
Locus tag HT135_RS07175 Protein ID WP_024121090.1
Coordinates 1389991..1390161 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HT135_RS07140 1386857..1387186 + 330 WP_106020448.1 XkdW family protein -
HT135_RS07145 1387183..1387347 + 165 WP_106020447.1 XkdX family protein -
HT135_RS07150 1387391..1388230 + 840 WP_106020446.1 phage-like element PBSX protein XepA -
HT135_RS07155 1388283..1388552 + 270 WP_106020445.1 hemolysin XhlA family protein -
HT135_RS07160 1388564..1388827 + 264 WP_106020444.1 phage holin -
HT135_RS07165 1388840..1389733 + 894 WP_101860749.1 N-acetylmuramoyl-L-alanine amidase -
HT135_RS07170 1389770..1389907 - 138 WP_142396753.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
HT135_RS07175 1389991..1390161 - 171 WP_024121090.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
HT135_RS07180 1390161..1390907 - 747 WP_024121091.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
HT135_RS07185 1391016..1392017 - 1002 WP_024121092.1 inorganic phosphate transporter family protein -
HT135_RS07190 1392030..1392647 - 618 WP_010333926.1 DUF47 domain-containing protein -
HT135_RS07195 1392924..1394240 - 1317 WP_099042852.1 serine/threonine exchanger -
HT135_RS07200 1394635..1395585 + 951 WP_024121094.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29076.48 Da        Isoelectric Point: 4.4986

>T159946 WP_024121091.1 NZ_CP054584:c1390907-1390161 [Bacillus halotolerans]
MLLFFQIMVWCTMAALGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMIYWTYDPSSLFTNWERYVIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLDRLKTYQYLLKNEPIHVYYGSIEAYAEGIDKLLKTYADKMNLTASL
CHYSTQSDKDRLTEHMEDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQSYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

>T159946 NZ_CP070227:c767924-767586 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCTCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAAGAGAGCAAA
CTGATGCAGTCACTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAGTTTATTGGGGTGATTAG
TAGCAAAACGCCACGCTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6578.62 Da        Isoelectric Point: 10.9236

>AT159946 WP_024121090.1 NZ_CP054584:c1390161-1389991 [Bacillus halotolerans]
MENAFQNGCHPRAKKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp

>AT159946 NZ_CP070227:767942-767995 [Escherichia coli]
AATAGGGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G7U9Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A7G7U9Y3

References