159942

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5444777..5445385 Replicon chromosome
Accession NZ_CP054581
Organism Pseudomonas aeruginosa strain YTSEY8

Toxin (Protein)


Gene name PfiT Uniprot ID A0A1B1XUZ2
Locus tag HUF04_RS25935 Protein ID WP_003123043.1
Coordinates 5444777..5445124 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag HUF04_RS25940 Protein ID WP_003114155.1
Coordinates 5445134..5445385 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUF04_RS25905 5440136..5440408 + 273 WP_021264275.1 cysteine-rich CWC family protein -
HUF04_RS25910 5440408..5441100 + 693 WP_003085458.1 16S rRNA pseudouridine(516) synthase -
HUF04_RS25915 5441236..5442279 + 1044 WP_003134392.1 L,D-transpeptidase -
HUF04_RS25920 5442359..5443096 + 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
HUF04_RS25925 5443548..5444450 + 903 WP_003163340.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
HUF04_RS25935 5444777..5445124 - 348 WP_003123043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUF04_RS25940 5445134..5445385 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HUF04_RS25945 5445599..5446582 - 984 WP_003114154.1 tyrosine-type recombinase/integrase -
HUF04_RS25950 5446582..5447874 - 1293 WP_003123045.1 hypothetical protein -
HUF04_RS25955 5448133..5449395 - 1263 WP_033953311.1 hypothetical protein -
HUF04_RS25960 5449397..5449747 - 351 WP_003133726.1 DUF2523 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 5444777..5465298 20521


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12990.74 Da        Isoelectric Point: 4.4212

>T159942 WP_003123043.1 NZ_CP054581:c5445124-5444777 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T159942 NZ_CP070174:53605-53910 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCTGTGAACTCTATCCGGTGG
TGCACATCGGGGACGACAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT159942 WP_003114155.1 NZ_CP054581:c5445385-5445134 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT159942 NZ_CP070174:53385-53603 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACCGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCTGAAAATCAGGAAGGAATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1XUZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References