Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 156187..156692 Replicon chromosome
Accession NZ_CP054581
Organism Pseudomonas aeruginosa strain YTSEY8

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag HUF04_RS00735 Protein ID WP_003083773.1
Coordinates 156187..156468 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag HUF04_RS00740 Protein ID WP_003083775.1
Coordinates 156465..156692 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUF04_RS00710 151438..152787 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
HUF04_RS00715 152836..153522 + 687 WP_003083762.1 FadR family transcriptional regulator -
HUF04_RS00720 153623..154357 + 735 WP_003117208.1 GntR family transcriptional regulator -
HUF04_RS00725 154561..154947 + 387 WP_014602345.1 aegerolysin family protein -
HUF04_RS00730 154979..155887 - 909 WP_003083769.1 LysR family transcriptional regulator -
HUF04_RS00735 156187..156468 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
HUF04_RS00740 156465..156692 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
HUF04_RS00745 156868..157488 - 621 WP_003101226.1 hypothetical protein -
HUF04_RS00750 157589..158089 + 501 WP_034040605.1 LEA type 2 family protein -
HUF04_RS00755 158162..158503 + 342 WP_003101229.1 alkylphosphonate utilization protein -
HUF04_RS00760 158585..160012 - 1428 WP_003083784.1 GABA permease -
HUF04_RS00765 160181..161674 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T159937 WP_003083773.1 NZ_CP054581:c156468-156187 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T159937 NZ_CP070172:c4229353-4229251 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT159937 WP_003083775.1 NZ_CP054581:c156692-156465 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT159937 NZ_CP070172:4229244-4229389 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References