Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 5507283..5508400 Replicon chromosome
Accession NZ_CP054580
Organism Halomonas titanicae strain GPM3

Toxin (Protein)


Gene name - Uniprot ID A0A654B714
Locus tag FX987_RS25680 Protein ID WP_022519609.1
Coordinates 5507651..5508400 (+) Length 250 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A7Z0LWE6
Locus tag FX987_RS25675 Protein ID WP_022519610.1
Coordinates 5507283..5507654 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FX987_RS25655 5503288..5503821 + 534 WP_022519614.1 GDYXXLXY domain-containing protein -
FX987_RS25660 5504011..5505738 + 1728 WP_022519613.1 mechanosensitive ion channel -
FX987_RS25665 5505831..5506262 + 432 WP_022519612.1 transcriptional regulator -
FX987_RS25670 5506279..5507055 - 777 WP_022519611.1 aspartate/glutamate racemase family protein -
FX987_RS25675 5507283..5507654 + 372 WP_022519610.1 DUF2384 domain-containing protein Antitoxin
FX987_RS25680 5507651..5508400 + 750 WP_022519609.1 RES family NAD+ phosphorylase Toxin
FX987_RS25685 5508478..5509242 + 765 WP_022519608.1 prolyl oligopeptidase family serine peptidase -
FX987_RS25690 5509342..5509836 - 495 WP_022519607.1 RidA family protein -
FX987_RS25695 5509895..5510290 - 396 WP_089691607.1 cytochrome c -
FX987_RS25700 5510310..5511896 - 1587 WP_022519605.1 flavin monoamine oxidase family protein -
FX987_RS25705 5512221..5512583 - 363 WP_035538936.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(62-206)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(9-68)


Sequences

Toxin        


Download         Length: 250 a.a.        Molecular weight: 27774.54 Da        Isoelectric Point: 5.8853

>T159935 WP_022519609.1 NZ_CP054580:5507651-5508400 [Halomonas titanicae]
VSVWEACGGARNIKPISGTLYRLVESQEQVATLSYVDTLEEQEMLEALLETAKPPYPEQERDLHYLLKTPFRYPPLKWGS
RFGRVFEPSIFYGGKGIATTLAESAYYRLVFWYSMEGDPVTASLRSEHTLFSVDYAAKRGVRLYAGFFVDHLAVLKHPVD
YAPCQQLGSAMRGAGVEAFEYASARDIQGGACVGLFTPDALAQHEPADMRPWLCVTSAAQVSFKRKDASGVYTYHLDDFL
HQGVLPFPA

Download         Length: 750 bp

>T159935 NZ_CP070172:2289949-2290266 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGTCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13447.81 Da        Isoelectric Point: 11.0983

>AT159935 WP_022519610.1 NZ_CP054580:5507283-5507654 [Halomonas titanicae]
MPALTQTKPTPEMVLAKAVLRAAEQLGLSQSDLAEVLGVHRTTITQLKKSLKLDPNSKQGELALLLIRLARALFALTGGD
QTWIQHFMRTSNRVTGGIPAEQVTRLEGLFAVLRFVDGMRGKV

Download         Length: 372 bp

>AT159935 NZ_CP070172:2290259-2290546 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A654B714

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z0LWE6

References