Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 5291993..5292540 Replicon chromosome
Accession NZ_CP054580
Organism Halomonas titanicae strain GPM3

Toxin (Protein)


Gene name parE Uniprot ID A0A1G8RBJ9
Locus tag FX987_RS24635 Protein ID WP_022519911.1
Coordinates 5291993..5292292 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1G8RCM5
Locus tag FX987_RS24640 Protein ID WP_022519910.1
Coordinates 5292292..5292540 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FX987_RS24615 5287041..5288516 - 1476 WP_022519915.1 BCCT family transporter -
FX987_RS24620 5288547..5289740 - 1194 WP_022519914.1 Xaa-Pro peptidase family protein -
FX987_RS24625 5289747..5290928 - 1182 WP_022519913.1 amidohydrolase -
FX987_RS24630 5291084..5291989 + 906 WP_053856892.1 LysR family transcriptional regulator -
FX987_RS24635 5291993..5292292 - 300 WP_022519911.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FX987_RS24640 5292292..5292540 - 249 WP_022519910.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FX987_RS24645 5292813..5293763 + 951 WP_089691615.1 DUF808 domain-containing protein -
FX987_RS24650 5293855..5295027 - 1173 WP_022519908.1 MFS transporter -
FX987_RS24655 5295116..5295616 + 501 WP_022519907.1 Lrp/AsnC family transcriptional regulator -
FX987_RS24660 5295764..5296258 - 495 WP_022519906.1 hypothetical protein -
FX987_RS24665 5296419..5297291 - 873 WP_022519905.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-91)

Antitoxin

Antitoxin ParD

(3-67)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11913.58 Da        Isoelectric Point: 8.8074

>T159933 WP_022519911.1 NZ_CP054580:c5292292-5291993 [Halomonas titanicae]
MPRFHITPRARDDLKDIGRYTEWQWGKNQRNTYLRDFEKRFHWLAENPLLGKHRSDISKGYYSYPQGQHVIFYLIGQGCI
EIIGIPHKEMDIVSYFLPD

Download         Length: 300 bp

>T159933 NZ_CP070172:1511146-1511679 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGTATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9034.93 Da        Isoelectric Point: 4.2690

>AT159933 WP_022519910.1 NZ_CP054580:c5292540-5292292 [Halomonas titanicae]
MATTSLSLGEHWEVFIRNEVASGRYGSASEVVRDALRSMEERKSKLEALRTHLAQGAEQASAGEFVDDFSMDALINDLDS
ET

Download         Length: 249 bp

>AT159933 NZ_CP070172:1510869-1511135 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1G8RBJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A1G8RCM5

References