Detailed information of TA system TA159931

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 5159918..5160590
• Replicon: chromosome
• Accession: NZ_CP054580
• Organism: Halomonas titanicae strain GPM3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A6N0Z6W4
• Locus tag: FX987_RS24070
• Protein ID: WP_022520048.1
• Coordinates: 5160216..5160590 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FX987_RS24065
• Protein ID: WP_022520049.1
• Coordinates: 5159918..5160223 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FX987_RS24045	5155359..5156339	-	981	WP_022520053.1	ABC transporter permease	-
FX987_RS24050	5156416..5157972	-	1557	WP_022520052.1	ABC transporter substrate-binding protein	-
FX987_RS24055	5158183..5158908	+	726	WP_022520051.1	GntR family transcriptional regulator	-
FX987_RS24060	5158886..5159914	+	1029	WP_053856899.1	histone deacetylase family protein	-
FX987_RS24065	5159918..5160223	-	306	WP_022520049.1	DNA-binding transcriptional regulator	Antitoxin
FX987_RS24070	5160216..5160590	-	375	WP_022520048.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FX987_RS24075	5160756..5164421	+	3666	WP_022520047.1	ATP-binding protein	-
FX987_RS24080	5164418..5165053	+	636	WP_022520046.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-120)

Antitoxin

• Cro/C1-type helix-turn-helix domain (45-89)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13295.50 Da
• Isoelectric Point: 10.3327

>T159931 WP_022520048.1 NZ_CP054580:c5160590-5160216 [Halomonas titanicae]
MRVFKNKVFSKWAAKEGLDDAALLAAVEEMERGLIDADLGGHVVKKRVAIGGRGKSGGARTLLAYKIGNKAFFVYGFAKN
ARANISAEELKALKHLAKELLGYGEKALAEAIKHGALIEVKNDG

Nucleotide

• Length: 375 bp

>T159931 NZ_CP070172:1399519-1399803 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCTGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11218.02 Da
• Isoelectric Point: 8.9798

>AT159931 WP_022520049.1 NZ_CP054580:c5160223-5159918 [Halomonas titanicae]
MDKSILDMVHETAQDLHAAGVMKETTLREFDALCLPPVKEYTAIQIKRIRTKNHASQGVFAAYLNTSVSTVQKWEQGQKK
PNGPSLKLLNLVAEKGLEILA

Nucleotide

• Length: 306 bp

>AT159931 NZ_CP070172:1399287-1399529 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: A0A6N0Z6W4