Detailed information of TA system TA159930

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4663869..4664509
• Replicon: chromosome
• Accession: NZ_CP054580
• Organism: Halomonas titanicae strain GPM3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FX987_RS21650
• Protein ID: WP_082116825.1
• Coordinates: 4664327..4664509 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A653T028
• Locus tag: FX987_RS21645
• Protein ID: WP_022520765.1
• Coordinates: 4663869..4664288 (-)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FX987_RS21620	4660987..4661769	+	783	WP_009287879.1	sulfite exporter TauE/SafE family protein	-
FX987_RS21625	4661780..4662964	-	1185	WP_082116912.1	MFS transporter	-
FX987_RS21630	4663083..4663262	-	180	WP_022520767.1	hypothetical protein	-
FX987_RS21635	4663259..4663324	-	66	WP_138800243.1	type II toxin-antitoxin system HigB family toxin	-
FX987_RS21640	4663380..4663535	-	156	WP_022520766.1	DUF4113 domain-containing protein	-
FX987_RS21645	4663869..4664288	-	420	WP_022520765.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FX987_RS21650	4664327..4664509	-	183	WP_082116825.1	type II toxin-antitoxin system HicA family toxin	Toxin
FX987_RS21655	4664839..4665195	-	357	WP_022520764.1	type II toxin-antitoxin system HicB family antitoxin	-
FX987_RS21660	4665192..4665320	-	129	Protein_4260	type II toxin-antitoxin system HicA family toxin	-
FX987_RS21665	4665764..4667110	+	1347	WP_174788353.1	site-specific integrase	-
FX987_RS21670	4667105..4667413	-	309	WP_174788354.1	hypothetical protein	-
FX987_RS21675	4667410..4667730	-	321	WP_174788355.1	hypothetical protein	-
FX987_RS21680	4667869..4668090	-	222	WP_174788356.1	TraR/DksA family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4663083..4709547	46464

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6790.93 Da
• Isoelectric Point: 11.4650

>T159930 WP_082116825.1 NZ_CP054580:c4664509-4664327 [Halomonas titanicae]
VDSRTLIKELKKDGWELVRVNGSHHHFRHPTKPGTVTVPHPKKDLKTGLVRAIRKSAGFL

Nucleotide

• Length: 183 bp

>T159930 NZ_CP070172:1235207-1236124 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCAATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15176.16 Da
• Isoelectric Point: 4.4306

>AT159930 WP_022520765.1 NZ_CP054580:c4664288-4663869 [Halomonas titanicae]
MLFPIAIERGDEQHAYGVVVPDLNGCFSAGDTFEEALANVKAAIEGWLEVAVDYGDPIPEATSIEHHMDNPEYAGWIWAV
VDIDLTPYLGKSHKINVTLPDLLVKQIDDFVASHPGDKTRSGFLSRVAMAELARARKGA

Nucleotide

• Length: 420 bp

>AT159930 NZ_CP070172:1234443-1235201 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A653T028