Detailed information of TA system TA159929

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 3975793..3976703
• Replicon: chromosome
• Accession: NZ_CP054580
• Organism: Halomonas titanicae strain GPM3

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FX987_RS18340
• Protein ID: WP_022521349.1
• Coordinates: 3976239..3976703 (+)
• Length: 155 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A653Z8I6
• Locus tag: FX987_RS18335
• Protein ID: WP_022521350.1
• Coordinates: 3975793..3976242 (+)
• Length: 150 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FX987_RS18315	3972317..3972637	-	321	WP_022521354.1	urease subunit beta	-
FX987_RS18320	3972791..3973093	-	303	WP_022521353.1	urease subunit gamma	-
FX987_RS18325	3973131..3974015	-	885	WP_022521352.1	urease accessory protein UreD	-
FX987_RS18330	3974243..3975604	-	1362	WP_022521351.1	diguanylate cyclase	-
FX987_RS18335	3975793..3976242	+	450	WP_022521350.1	DUF2384 domain-containing protein	Antitoxin
FX987_RS18340	3976239..3976703	+	465	WP_022521349.1	RES family NAD+ phosphorylase	Toxin
FX987_RS18345	3976946..3977914	+	969	WP_009286156.1	zinc ABC transporter substrate-binding protein	-
FX987_RS18350	3977938..3978720	+	783	WP_174788328.1	ABC transporter ATP-binding protein	-
FX987_RS18355	3978724..3979833	+	1110	WP_022521347.1	metal ABC transporter permease	-
FX987_RS18360	3979830..3980750	+	921	WP_009286158.1	metal ABC transporter permease	-
FX987_RS18365	3980848..3981555	-	708	WP_022521346.1	urea ABC transporter ATP-binding subunit UrtE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (6-149)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (31-90)

Sequences

Toxin

Protein

• Length: 155 a.a.
• Molecular weight: 16840.13 Da
• Isoelectric Point: 4.1956

>T159929 WP_022521349.1 NZ_CP054580:3976239-3976703 [Halomonas titanicae]
MSEVTAYRLVKRKFQETAFDGEGARLYGGRWNSPGNACVYVASYESLALLEIMVNLESYRLLNAYALLRLTLPADSILSI
GAEDLPENWQEAPAPAETAELGDGWLASGQSLALAVSSVVVPRELNYMLNPAHPLFDQIVATAEALPFQPDPRL

Nucleotide

• Length: 465 bp

>T159929 NZ_CP070172:917598-917981 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 150 a.a.
• Molecular weight: 16672.13 Da
• Isoelectric Point: 10.0368

>AT159929 WP_022521350.1 NZ_CP054580:3975793-3976242 [Halomonas titanicae]
MDIHFTQYQPPKALASGFWQQIGLPARGRKLHELLHEGVEYRVYPQIAKVSGIEQKALARYVDIPSATLSRRAKSGRFKM
AESDRLYRFAELFKAALDLFEGDSEGARAWLLKPNAGLGGRRPVEMSATSAEYQTVLNLIGRLEHGVSV

Nucleotide

• Length: 450 bp

>AT159929 NZ_CP070172:917356-917598 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A653Z8I6