Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 3493112..3493622 Replicon chromosome
Accession NZ_CP054580
Organism Halomonas titanicae strain GPM3

Toxin (Protein)


Gene name relB Uniprot ID A0A653XY69
Locus tag FX987_RS16235 Protein ID WP_022521756.1
Coordinates 3493359..3493622 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A653XX99
Locus tag FX987_RS16230 Protein ID WP_022521757.1
Coordinates 3493112..3493366 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FX987_RS16210 3488202..3489650 - 1449 WP_022521762.1 sensor domain-containing diguanylate cyclase -
FX987_RS16215 3489928..3491193 + 1266 WP_022521761.1 cytosine permease -
FX987_RS16220 3491210..3492463 + 1254 WP_022521760.1 cytosine deaminase -
FX987_RS16225 3492541..3493017 + 477 WP_022521759.1 YbaK/EbsC family protein -
FX987_RS16230 3493112..3493366 + 255 WP_022521757.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FX987_RS16235 3493359..3493622 + 264 WP_022521756.1 Txe/YoeB family addiction module toxin Toxin
FX987_RS16240 3493624..3494079 - 456 WP_022521755.1 rhodanese-like sulfurtransferase -
FX987_RS16245 3494090..3494539 - 450 WP_022521754.1 GNAT family N-acetyltransferase -
FX987_RS16250 3494632..3496107 + 1476 WP_022521753.1 PLP-dependent aminotransferase family protein -
FX987_RS16255 3496324..3496989 + 666 WP_022521752.1 CDP-alcohol phosphatidyltransferase family protein -
FX987_RS16260 3497004..3497606 + 603 WP_022521751.1 DNA-3-methyladenine glycosylase I -
FX987_RS16265 3497629..3498033 + 405 WP_022521750.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10422.85 Da        Isoelectric Point: 8.4783

>T159928 WP_022521756.1 NZ_CP054580:3493359-3493622 [Halomonas titanicae]
MSNRLLCWTNEAWSDYLYWQGQDKKTLKRINKLILDTQRSPFEGIGKPEPLRENLSGFWSRRIDDSHRLIYAVDESTLTI
IACRYHY

Download         Length: 264 bp

>T159928 NZ_CP070172:c508904-508536 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9437.63 Da        Isoelectric Point: 4.5388

>AT159928 WP_022521757.1 NZ_CP054580:3493112-3493366 [Halomonas titanicae]
MRVISFTEARNGLKGVLDGVVNDADTTIITRRDAEDAVVMSLDYYNSLMETVYLMRSPANAEHLNKSIAQYRAGQAQPRE
LMDE

Download         Length: 255 bp

>AT159928 NZ_CP070172:c509122-508901 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A653XY69

Antitoxin

Source ID Structure
AlphaFold DB A0A653XX99

References