Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 2315117..2316063 Replicon chromosome
Accession NZ_CP054580
Organism Halomonas titanicae strain GPM3

Toxin (Protein)


Gene name slvT Uniprot ID L9U964
Locus tag FX987_RS10725 Protein ID WP_009287632.1
Coordinates 2315117..2315635 (-) Length 173 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A6N0YYX8
Locus tag FX987_RS10730 Protein ID WP_022522688.1
Coordinates 2315632..2316063 (-) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FX987_RS10700 2310846..2311118 + 273 WP_008958942.1 XRE family transcriptional regulator -
FX987_RS10705 2311246..2312439 - 1194 WP_022522692.1 chromate efflux transporter -
FX987_RS10710 2312552..2314234 - 1683 WP_022522691.1 dihydroxy-acid dehydratase -
FX987_RS10715 2314407..2314703 + 297 WP_022522690.1 type II toxin-antitoxin system RelE/ParE family toxin -
FX987_RS10720 2314708..2315022 + 315 WP_022522689.1 putative addiction module antidote protein -
FX987_RS10725 2315117..2315635 - 519 WP_009287632.1 RES domain-containing protein Toxin
FX987_RS10730 2315632..2316063 - 432 WP_022522688.1 DUF2384 domain-containing protein Antitoxin
FX987_RS10735 2316240..2319869 + 3630 WP_022522687.1 exodeoxyribonuclease V subunit gamma -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(11-163)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 19535.15 Da        Isoelectric Point: 5.2387

>T159927 WP_009287632.1 NZ_CP054580:c2315635-2315117 [Halomonas titanicae]
MIVLPELKTQAYRVHVPRWAFSPTSGAGAREHGGRLNRVGVDALYLSLEEQTALAEYKQLSALMPPGLIVSYTVSVTTIV
DFRSGYNSKWDSLWQELNCDWRKYWFNQRIEPPSWILGDMALEQGAKGILFPSLARDSGTNLVLYTETLTENDMLEVYDP
KGDLPHNARSWQ

Download         Length: 519 bp

>T159927 NZ_CP070172:c482933-482586 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
ATTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 15910.98 Da        Isoelectric Point: 6.4879

>AT159927 WP_022522688.1 NZ_CP054580:c2316063-2315632 [Halomonas titanicae]
MAIDTVKESLNESSGYLVPDSFERFLADLKGAARKDRHPLINPKLFASALSIDIQTLANQAHVHRTTISRAQGAEKLQRY
LRDALRVLGAAADINGDFHDALFWFRNEPLSAFDYKTPEQLVSEGRAEDLLRYVQALQAGVVG

Download         Length: 432 bp

>AT159927 NZ_CP070172:c482586-482287 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGATAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB L9U964

Antitoxin

Source ID Structure
AlphaFold DB A0A6N0YYX8

References