Detailed information of TA system TA159926

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 2314407..2315022
• Replicon: chromosome
• Accession: NZ_CP054580
• Organism: Halomonas titanicae strain GPM3

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: A0A1G8NTB1
• Locus tag: FX987_RS10715
• Protein ID: WP_022522690.1
• Coordinates: 2314407..2314703 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FX987_RS10720
• Protein ID: WP_022522689.1
• Coordinates: 2314708..2315022 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FX987_RS10695	2310111..2310626	-	516	WP_022522693.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
FX987_RS10700	2310846..2311118	+	273	WP_008958942.1	XRE family transcriptional regulator	-
FX987_RS10705	2311246..2312439	-	1194	WP_022522692.1	chromate efflux transporter	-
FX987_RS10710	2312552..2314234	-	1683	WP_022522691.1	dihydroxy-acid dehydratase	-
FX987_RS10715	2314407..2314703	+	297	WP_022522690.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FX987_RS10720	2314708..2315022	+	315	WP_022522689.1	putative addiction module antidote protein	Antitoxin
FX987_RS10725	2315117..2315635	-	519	WP_009287632.1	RES domain-containing protein	-
FX987_RS10730	2315632..2316063	-	432	WP_022522688.1	DUF2384 domain-containing protein	-
FX987_RS10735	2316240..2319869	+	3630	WP_022522687.1	exodeoxyribonuclease V subunit gamma	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-96)

Antitoxin

• Uncharacterized protein HI1420 (8-94)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11045.95 Da
• Isoelectric Point: 10.2250

>T159926 WP_022522690.1 NZ_CP054580:2314407-2314703 [Halomonas titanicae]
MIELIKTDVFDRWLRELRDIRARAKVEARIRRLSLGNPGDVKPVGKGVSELRIPYGPGYRVYYITKGPVIVVLLCGGDKA
TQSHDIELAKAIAAQWKE

Nucleotide

• Length: 297 bp

>T159926 NZ_CP070172:c112955-112467 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTGTGTTGCGGCAGCGATTCTAACGTAC
TGGCGTATTACTCGCTCGCGTCCAGTGCGGTAATGACTAACACCGCCCCCGGTCGCTTTCGTCGCAATATGCCCGATCCG
ATCCCGGTAGTAGTGCTGGGGCGTCTGGCGGTGGATCAGTCTCTACATGGACGGGGCGTAGGTCGGGCGCTGGTGAGGGA
TGCCGGGCTGCGGGTGATTCAGGTGGCGGAAACTATCGGTATTCGGGGAATGCTGGTTCATGCCCTGTCGGATGAAGCGC
GGGAGTTTTATCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGCTGATGGTGACGTTGGGGGATTTGGTT
CATGCCTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11074.48 Da
• Isoelectric Point: 4.4217

>AT159926 WP_022522689.1 NZ_CP054580:2314708-2315022 [Halomonas titanicae]
MTVPNVTFSHYDTADYLQTEEDIAAYLDAVMEENDPALLAAALGDIARARNMSQLAKDVGMSREGLYKALSGEGNPAFAT
ISKVANSLGLRLSIKPLSRPEAGS

Nucleotide

• Length: 315 bp

>AT159926 NZ_CP070172:c113245-112952 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Structures

Toxin

• AlphaFold DB: A0A1G8NTB1