Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-YefM
Location 96925..97427 Replicon chromosome
Accession NZ_CP054580
Organism Halomonas titanicae strain GPM3

Toxin (Protein)


Gene name yoeB Uniprot ID A0A653MLQ3
Locus tag FX987_RS00450 Protein ID WP_022520614.1
Coordinates 96925..97179 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A653MNW0
Locus tag FX987_RS00455 Protein ID WP_022520613.1
Coordinates 97176..97427 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FX987_RS00420 92419..93606 + 1188 WP_053856853.1 pyridoxal phosphate-dependent aminotransferase -
FX987_RS00425 93979..94167 + 189 WP_022520619.1 tautomerase family protein -
FX987_RS00430 94518..94994 + 477 WP_170834099.1 GNAT family N-acetyltransferase -
FX987_RS00435 95058..95420 + 363 WP_027959862.1 DUF1304 domain-containing protein -
FX987_RS00440 95540..96124 + 585 WP_022520616.1 HD domain-containing protein -
FX987_RS00445 96214..96669 + 456 WP_022520615.1 GNAT family N-acetyltransferase -
FX987_RS00450 96925..97179 - 255 WP_022520614.1 Txe/YoeB family addiction module toxin Toxin
FX987_RS00455 97176..97427 - 252 WP_022520613.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FX987_RS00460 97584..97823 - 240 WP_053856851.1 hypothetical protein -
FX987_RS00465 97984..98919 + 936 WP_022520611.1 LysR family transcriptional regulator -
FX987_RS00470 98886..99905 - 1020 WP_022520610.1 NADP-dependent oxidoreductase -
FX987_RS00475 99995..100897 + 903 WP_027959856.1 LysR family transcriptional regulator -
FX987_RS00480 101221..101470 - 250 Protein_95 manganese efflux pump -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10227.83 Da        Isoelectric Point: 9.8162

>T159925 WP_022520614.1 NZ_CP054580:c97179-96925 [Halomonas titanicae]
MKLIFSESAWEDYLYWQKTDKKILNRINKLIKETKREPFEGVGKPEPLKHSLAGYWSRRINEEHRMVYKVTDDALLIAQL
RYHY

Download         Length: 255 bp

>T159925 NZ_CP070172:c42685-42275 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9285.56 Da        Isoelectric Point: 4.4750

>AT159925 WP_022520613.1 NZ_CP054580:c97427-97176 [Halomonas titanicae]
MDAISYTAARTNLAKTMEQVCEDHSPMIITRSKAQSVVMISLEDYEALQETAYLLRAPKNARRLLESVAELEQGGGQEKE
LLE

Download         Length: 252 bp

>AT159925 NZ_CP070172:c42932-42666 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A653MLQ3

Antitoxin

Source ID Structure
AlphaFold DB A0A653MNW0

References