Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_26(antitoxin)
Location 1891207..1892014 Replicon chromosome
Accession NZ_CP054575
Organism Staphylococcus saprophyticus strain UTI-050

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag HSZ50_RS09325 Protein ID WP_174605057.1
Coordinates 1891529..1892014 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag HSZ50_RS09320 Protein ID WP_174605028.1
Coordinates 1891207..1891524 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HSZ50_RS09265 1886280..1887068 - 789 WP_069796340.1 phage replisome organizer N-terminal domain-containing protein -
HSZ50_RS09270 1887040..1887306 - 267 WP_069796341.1 helix-turn-helix domain-containing protein -
HSZ50_RS09275 1887303..1887971 - 669 WP_174605022.1 hypothetical protein -
HSZ50_RS09280 1887985..1888425 - 441 WP_145441193.1 single-stranded DNA-binding protein -
HSZ50_RS09285 1888422..1889066 - 645 WP_145441195.1 ERF family protein -
HSZ50_RS09290 1889067..1889558 - 492 WP_145441197.1 siphovirus Gp157 family protein -
HSZ50_RS09295 1889635..1889793 - 159 WP_174605023.1 hypothetical protein -
HSZ50_RS09300 1889795..1890001 - 207 WP_174605024.1 hypothetical protein -
HSZ50_RS09305 1890014..1890223 - 210 WP_174605025.1 DUF771 domain-containing protein -
HSZ50_RS09310 1890213..1890791 - 579 WP_174605026.1 hypothetical protein -
HSZ50_RS09315 1890827..1891045 - 219 WP_174605027.1 helix-turn-helix domain-containing protein -
HSZ50_RS09320 1891207..1891524 + 318 WP_174605028.1 helix-turn-helix domain-containing protein Antitoxin
HSZ50_RS09325 1891529..1892014 + 486 WP_174605057.1 ImmA/IrrE family metallo-endopeptidase Toxin
HSZ50_RS09330 1892011..1892988 + 978 WP_174605029.1 DUF5067 domain-containing protein -
HSZ50_RS09335 1893047..1894120 + 1074 WP_174605030.1 site-specific integrase -
HSZ50_RS09350 1894582..1895148 - 567 WP_011303464.1 competence protein ComK -
HSZ50_RS09355 1895400..1895618 + 219 WP_011303465.1 IDEAL domain-containing protein -
HSZ50_RS09360 1895700..1896689 - 990 WP_002483734.1 lipoate--protein ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1851232..1894120 42888


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(32-121)

Antitoxin

Cro/C1-type helix-turn-helix domain

(8-63)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 19083.71 Da        Isoelectric Point: 6.4924

>T159916 WP_174605057.1 NZ_CP054575:1891529-1892014 [Staphylococcus saprophyticus]
MGRYEELMNVYHDEIYIDDTYSLCGKFKGFYDNGVILIDKHLPQHHRLEILAEEIAHHKLTYGDITDQSVFNNRKFEGYA
RRHAMENIISIQGIIDAFKNNLHNLYEVANYFEVSEGFVQQCIINLKLRYGLSTIYKGYLIQFEPLRVFEYKKLNSRGYV
E

Download         Length: 486 bp

>T159916 NZ_CP070170:c2876134-2875754 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTTGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGCAGGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11941.47 Da        Isoelectric Point: 5.9249

>AT159916 WP_174605028.1 NZ_CP054575:1891207-1891524 [Staphylococcus saprophyticus]
MRNSEQIGKYIKQLRKTNNISVTALAEKVGINKSTLSRYENGSRKIPMEDIANFANALGVTPENILFEEKQDDTIAAHLE
DDDFTEDELKKIRDFADIVRKARKG

Download         Length: 318 bp

>AT159916 NZ_CP070170:c2876555-2876181 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGTATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References