Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 983239..984045 Replicon chromosome
Accession NZ_CP054575
Organism Staphylococcus saprophyticus strain UTI-050

Toxin (Protein)


Gene name tsbT Uniprot ID Q49YQ0
Locus tag HSZ50_RS04925 Protein ID WP_011302805.1
Coordinates 983860..984045 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q49YQ1
Locus tag HSZ50_RS04920 Protein ID WP_011302804.1
Coordinates 983239..983838 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HSZ50_RS04900 979117..980580 + 1464 WP_047502301.1 ABC transporter substrate-binding protein/permease -
HSZ50_RS04905 980573..981295 + 723 WP_002482873.1 amino acid ABC transporter ATP-binding protein -
HSZ50_RS04910 981456..982583 + 1128 WP_011302803.1 tRNA epoxyqueuosine(34) reductase QueG -
HSZ50_RS04915 982588..983058 + 471 WP_002482875.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
HSZ50_RS04920 983239..983838 + 600 WP_011302804.1 glucosamine-6-phosphate isomerase Antitoxin
HSZ50_RS04925 983860..984045 + 186 WP_011302805.1 hypothetical protein Toxin
HSZ50_RS04930 984202..984618 + 417 WP_011302806.1 hypothetical protein -
HSZ50_RS04935 984996..986381 + 1386 WP_011302807.1 class II fumarate hydratase -
HSZ50_RS04940 986584..987411 - 828 WP_011302808.1 RluA family pseudouridine synthase -
HSZ50_RS04945 987596..988711 + 1116 WP_011302809.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7056.51 Da        Isoelectric Point: 3.8237

>T159915 WP_011302805.1 NZ_CP054575:983860-984045 [Staphylococcus saprophyticus]
MSLDKNQNNLHRDELESENAMVDDLEDVVELGKEMEQISEENDEDKLDKSHDPAVRSDLNE

Download         Length: 186 bp

>T159915 NZ_CP070170:2671980-2672087 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22279.11 Da        Isoelectric Point: 4.8524

>AT159915 WP_011302804.1 NZ_CP054575:983239-983838 [Staphylococcus saprophyticus]
MAMNFKVLENEQVVAEYAADILRKQFNNNPTTIAGVHLSSDNAPVLDELKKNVDKHAVDFSQINILDYDNNKSYFEALGV
PEGQIFNVSFGEDTESFIKDKIKTKENKGKLITQVLSIDTNGKLDVSVNQGLFSAREVILIITGSDKKEVVHKLYEENGK
TSFEPSDLKAHRMVNVILDEAAAEGLPEDVRHYFTARFA

Download         Length: 600 bp

>AT159915 NZ_CP070170:c2671927-2671866 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380HKL3

Antitoxin

Source ID Structure
AlphaFold DB Q49YQ1

References