Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 816430..816944 Replicon chromosome
Accession NZ_CP054575
Organism Staphylococcus saprophyticus strain UTI-050

Toxin (Protein)


Gene name TsdT Uniprot ID A0A380HLI4
Locus tag HSZ50_RS03925 Protein ID WP_002482741.1
Coordinates 816738..816944 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q49Z35
Locus tag HSZ50_RS03920 Protein ID WP_002482740.1
Coordinates 816430..816723 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HSZ50_RS03895 811592..812383 + 792 WP_069825606.1 hydroxyethylthiazole kinase -
HSZ50_RS03900 812383..813021 + 639 WP_011302689.1 thiamine phosphate synthase -
HSZ50_RS03905 813109..813978 + 870 WP_011302690.1 membrane protein insertase YidC -
HSZ50_RS03910 814060..814734 - 675 WP_170178158.1 HD domain-containing protein -
HSZ50_RS03915 814803..816287 - 1485 WP_011302692.1 cardiolipin synthase -
HSZ50_RS03920 816430..816723 + 294 WP_002482740.1 copper-sensing transcriptional repressor CsoR Antitoxin
HSZ50_RS03925 816738..816944 + 207 WP_002482741.1 hypothetical protein Toxin
HSZ50_RS03930 817158..817298 + 141 WP_002482742.1 hypothetical protein -
HSZ50_RS03935 817591..818796 - 1206 WP_011302694.1 rod shape-determining protein RodA -
HSZ50_RS03940 819044..820114 + 1071 WP_011302695.1 D-alanine--D-alanine ligase -
HSZ50_RS03945 820127..821482 + 1356 WP_069794557.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 8052.33 Da        Isoelectric Point: 4.3776

>T159913 WP_002482741.1 NZ_CP054575:816738-816944 [Staphylococcus saprophyticus]
MQSKVIYIAELYNEKQKLQIEERLMKLYGVFKVSIDIEEGAIFVDFETPANLNNLEKEVYDLGYKIIY

Download         Length: 207 bp

>T159913 NZ_CP070170:2414643-2415965 [Escherichia coli]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGAGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAATGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACTGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAGTATTACTGTTTGCTGCTGGCGAAAGAACTCG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCAAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACAGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTATGACATCATTTCGGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGGTCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11221.90 Da        Isoelectric Point: 6.3282

>AT159913 WP_002482740.1 NZ_CP054575:816430-816723 [Staphylococcus saprophyticus]
MTEIQKAHHSEEIKANLKSRLNRIEGQVKAINRMVEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVEQGHE
QEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT159913 NZ_CP070170:2414377-2414643 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAATGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAACGGCTGGAC
GCAGAGCGAGTTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTAACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCAAAAAATGCCTCGCCAGAAGCA
ACAGAACAGCAAGATCTGGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380HLI4

Antitoxin

Source ID Structure
AlphaFold DB A0A380HKS9

References