Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 5428524..5429029 Replicon chromosome
Accession NZ_CP054572
Organism Pseudomonas sp. FDAARGOS_761

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag FOC67_RS25310 Protein ID WP_003083773.1
Coordinates 5428748..5429029 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag FOC67_RS25305 Protein ID WP_003083775.1
Coordinates 5428524..5428751 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC67_RS25280 5423542..5425035 + 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
FOC67_RS25285 5425204..5426631 + 1428 WP_009314944.1 GABA permease -
FOC67_RS25290 5426713..5427054 - 342 WP_003101229.1 alkylphosphonate utilization protein -
FOC67_RS25295 5427127..5427627 - 501 WP_003101228.1 LEA type 2 family protein -
FOC67_RS25300 5427728..5428348 + 621 WP_009314940.1 hypothetical protein -
FOC67_RS25305 5428524..5428751 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
FOC67_RS25310 5428748..5429029 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
FOC67_RS25315 5429329..5430237 + 909 WP_003083769.1 LysR family transcriptional regulator -
FOC67_RS25320 5430269..5430655 - 387 WP_003083767.1 aegerolysin family protein -
FOC67_RS25325 5430859..5431593 - 735 WP_003110658.1 GntR family transcriptional regulator -
FOC67_RS25330 5431694..5432380 - 687 WP_003083762.1 FadR family transcriptional regulator -
FOC67_RS25335 5432429..5433778 - 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T159912 WP_003083773.1 NZ_CP054572:5428748-5429029 [Pseudomonas sp. FDAARGOS_761]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T159912 NZ_CP070170:2122784-2122886 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT159912 WP_003083775.1 NZ_CP054572:5428524-5428751 [Pseudomonas sp. FDAARGOS_761]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT159912 NZ_CP070170:c2122924-2122656 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References