Detailed information of TA system TA159910

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 2106371..2107592
• Replicon: chromosome
• Accession: NZ_CP054572
• Organism: Pseudomonas sp. FDAARGOS_761

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0H2Z8V4
• Locus tag: FOC67_RS10000
• Protein ID: WP_003110488.1
• Coordinates: 2106371..2106949 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FOC67_RS10005
• Protein ID: WP_003088112.1
• Coordinates: 2107038..2107592 (-)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC67_RS09985	2101646..2102923	+	1278	WP_003102743.1	TolC family protein	-
FOC67_RS09990	2102913..2105084	+	2172	WP_003088105.1	type I secretion system permease/ATPase	-
FOC67_RS09995	2105074..2106261	+	1188	WP_003139884.1	HlyD family efflux transporter periplasmic adaptor subunit	-
FOC67_RS10000	2106371..2106949	-	579	WP_003110488.1	HD domain-containing protein	Toxin
FOC67_RS10005	2107038..2107592	-	555	WP_003088112.1	helix-turn-helix domain-containing protein	Antitoxin
FOC67_RS10010	2107750..2109945	-	2196	WP_009314576.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
FOC67_RS10015	2109950..2110411	-	462	WP_003102736.1	(2Fe-2S)-binding protein	-
FOC67_RS10020	2110742..2111065	+	324	WP_003102734.1	multidrug efflux SMR transporter	-
FOC67_RS10025	2111078..2111476	+	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
FOC67_RS10030	2111473..2112024	-	552	WP_003139878.1	XRE family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (7-188)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21913.75 Da
• Isoelectric Point: 5.3655

>T159910 WP_003110488.1 NZ_CP054572:c2106949-2106371 [Pseudomonas sp. FDAARGOS_761]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T159910 NZ_CP070170:1823859-1824113 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT159910 WP_003088112.1 NZ_CP054572:c2107592-2107038 [Pseudomonas sp. FDAARGOS_761]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT159910 NZ_CP070170:1823611-1823862 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Structures

Toxin

• AlphaFold DB: A0A0H2Z8V4