Detailed information of TA system TA159909

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 1183883..1185141
• Replicon: chromosome
• Accession: NZ_CP054572
• Organism: Pseudomonas sp. FDAARGOS_761

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FOC67_RS05640
• Protein ID: WP_009315395.1
• Coordinates: 1184386..1185141 (+)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: FOC67_RS05635
• Protein ID: WP_003086329.1
• Coordinates: 1183883..1184251 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC67_RS05615	1180047..1180322	+	276	WP_023088486.1	zinc ribbon domain-containing protein	-
FOC67_RS05620	1180325..1180801	-	477	WP_003086322.1	hypothetical protein	-
FOC67_RS05625	1180879..1182468	+	1590	WP_003123191.1	aldehyde dehydrogenase family protein	-
FOC67_RS05630	1182524..1183810	+	1287	WP_003086327.1	FAD-binding oxidoreductase	-
FOC67_RS05635	1183883..1184251	+	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
FOC67_RS05640	1184386..1185141	+	756	WP_009315395.1	RES family NAD+ phosphorylase	Toxin
FOC67_RS05645	1185913..1187274	+	1362	WP_083842341.1	DNA recombination protein RmuC	-
FOC67_RS05650	1187429..1189972	-	2544	WP_009315399.1	acyl-homoserine-lactone acylase QuiP	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28226.31 Da
• Isoelectric Point: 7.7294

>T159909 WP_009315395.1 NZ_CP054572:1184386-1185141 [Pseudomonas sp. FDAARGOS_761]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRASQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T159909 NZ_CP070170:1823611-1823862 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT159909 WP_003086329.1 NZ_CP054572:1183883-1184251 [Pseudomonas sp. FDAARGOS_761]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT159909 NZ_CP070170:1823859-1824113 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Antitoxin

• AlphaFold DB: V6AJU7