Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 5199514..5200556 | Replicon | chromosome |
| Accession | NZ_CP054571 | ||
| Organism | Achromobacter xylosoxidans strain FDAARGOS_789 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | A0A0D6GAF2 |
| Locus tag | FOC83_RS24185 | Protein ID | WP_058207229.1 |
| Coordinates | 5199514..5200089 (-) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A972JB12 |
| Locus tag | FOC83_RS24190 | Protein ID | WP_024067903.1 |
| Coordinates | 5200086..5200556 (-) | Length | 157 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FOC83_RS24155 | 5195011..5195913 | + | 903 | WP_024067896.1 | bacteriophage abortive infection AbiH family protein | - |
| FOC83_RS24160 | 5195955..5196680 | - | 726 | WP_024067897.1 | CBASS effector endonuclease NucC | - |
| FOC83_RS24165 | 5196717..5197619 | - | 903 | WP_024067898.1 | nucleotidyltransferase domain-containing protein | - |
| FOC83_RS24170 | 5197619..5198119 | - | 501 | WP_024067899.1 | hypothetical protein | - |
| FOC83_RS24175 | 5198116..5198586 | - | 471 | WP_024067900.1 | hypothetical protein | - |
| FOC83_RS24180 | 5198583..5199497 | - | 915 | WP_024067901.1 | AAA family ATPase | - |
| FOC83_RS24185 | 5199514..5200089 | - | 576 | WP_058207229.1 | PIN domain-containing protein | Toxin |
| FOC83_RS24190 | 5200086..5200556 | - | 471 | WP_024067903.1 | helix-turn-helix domain-containing protein | Antitoxin |
| FOC83_RS24195 | 5200759..5201142 | + | 384 | WP_024067904.1 | RAQPRD family integrative conjugative element protein | - |
| FOC83_RS24200 | 5201139..5201372 | + | 234 | WP_013520781.1 | TIGR03758 family integrating conjugative element protein | - |
| FOC83_RS24205 | 5201389..5201748 | + | 360 | WP_024067905.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| FOC83_RS24210 | 5201762..5202160 | + | 399 | WP_058207559.1 | TIGR03750 family conjugal transfer protein | - |
| FOC83_RS24215 | 5202157..5202855 | + | 699 | WP_024067907.1 | TIGR03746 family integrating conjugative element protein | - |
| FOC83_RS24220 | 5202852..5203790 | + | 939 | WP_024067908.1 | TIGR03749 family integrating conjugative element protein | - |
| FOC83_RS24225 | 5203780..5205201 | + | 1422 | WP_024067909.1 | TIGR03752 family integrating conjugative element protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 5144239..5209816 | 65577 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21576.73 Da Isoelectric Point: 5.2880
>T159906 WP_058207229.1 NZ_CP054571:c5200089-5199514 [Achromobacter xylosoxidans]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLIKRPDLNRAQVDRTSDLMDRAIPDGVVEGY
EELVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNELLAAYGIEAQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDCFLEILLRQGLVQTTKVLATYRTIL
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLIKRPDLNRAQVDRTSDLMDRAIPDGVVEGY
EELVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNELLAAYGIEAQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDCFLEILLRQGLVQTTKVLATYRTIL
Download Length: 576 bp
>T159906 NZ_CP070170:858785-859192 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 157 a.a. Molecular weight: 17225.63 Da Isoelectric Point: 6.3803
>AT159906 WP_024067903.1 NZ_CP054571:c5200556-5200086 [Achromobacter xylosoxidans]
MTTTAAQSKMTLPAAAEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHLVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
MTTTAAQSKMTLPAAAEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHLVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
Download Length: 471 bp
>AT159906 NZ_CP070170:858538-858804 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATTCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATTCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|