Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 5085471..5086044 Replicon chromosome
Accession NZ_CP054571
Organism Achromobacter xylosoxidans strain FDAARGOS_789

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FOC83_RS23575 Protein ID WP_058207222.1
Coordinates 5085667..5086044 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FOC83_RS23570 Protein ID WP_054471260.1
Coordinates 5085471..5085680 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC83_RS23550 5080877..5081665 - 789 WP_024067852.1 helix-turn-helix transcriptional regulator -
FOC83_RS23555 5081764..5082690 + 927 WP_020924995.1 DMT family transporter -
FOC83_RS23560 5082703..5083521 - 819 WP_058207221.1 AAC(3) family N-acetyltransferase -
FOC83_RS23565 5083673..5085346 + 1674 WP_024067854.1 energy-dependent translational throttle protein EttA -
FOC83_RS23570 5085471..5085680 + 210 WP_054471260.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FOC83_RS23575 5085667..5086044 + 378 WP_058207222.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC83_RS23580 5086112..5086645 + 534 WP_024067855.1 isochorismatase family protein -
FOC83_RS23585 5086836..5087060 + 225 WP_006388976.1 glycine zipper 2TM domain-containing protein -
FOC83_RS23590 5087190..5087447 - 258 WP_006388977.1 cell division topological specificity factor MinE -
FOC83_RS23595 5087451..5088266 - 816 WP_006388978.1 septum site-determining protein MinD -
FOC83_RS23600 5088455..5089372 - 918 WP_024067857.1 septum site-determining protein MinC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13890.17 Da        Isoelectric Point: 6.3726

>T159905 WP_058207222.1 NZ_CP054571:5085667-5086044 [Achromobacter xylosoxidans]
MILVDTSIWIDHLSDGEPCLVRLLEEESVLMHPFIAGELALGSLGRRDVVLGTMSLLPQVVRASHDEVMHFLHSERLFGK
GIGYVDLHLLASTRLTPGAALWTREKRLQALATTLSLAVDPPRYH

Download         Length: 378 bp

>T159905 NZ_CP070170:c712604-712230 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7521.62 Da        Isoelectric Point: 9.9435

>AT159905 WP_054471260.1 NZ_CP054571:5085471-5085680 [Achromobacter xylosoxidans]
VRTTVTLDDDLLELARTYTGVQETSALVTRALTQLVQKEAAKRLAKLGGSSPKLKPIPRRQTETCNDPG

Download         Length: 210 bp

>AT159905 NZ_CP070170:c713062-712694 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACAGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References