Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 4164692..4165246 Replicon chromosome
Accession NZ_CP054571
Organism Achromobacter xylosoxidans strain FDAARGOS_789

Toxin (Protein)


Gene name relE Uniprot ID A0A0D6FFH4
Locus tag FOC83_RS19310 Protein ID WP_006386989.1
Coordinates 4164968..4165246 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D6FFH2
Locus tag FOC83_RS19305 Protein ID WP_024067400.1
Coordinates 4164692..4164898 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC83_RS19290 4161334..4162311 - 978 WP_024067397.1 tripartite tricarboxylate transporter substrate binding protein -
FOC83_RS19295 4162504..4163154 - 651 WP_024067398.1 hypothetical protein -
FOC83_RS19300 4163153..4164598 + 1446 WP_024067399.1 RNA polymerase factor sigma-54 -
FOC83_RS19305 4164692..4164898 + 207 WP_024067400.1 hypothetical protein Antitoxin
FOC83_RS19310 4164968..4165246 + 279 WP_006386989.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOC83_RS19315 4165425..4165724 + 300 WP_006386990.1 (2Fe-2S)-binding protein -
FOC83_RS19320 4165694..4166614 - 921 WP_006386991.1 LysR family transcriptional regulator -
FOC83_RS19325 4166728..4167642 + 915 WP_024067401.1 DMT family transporter -
FOC83_RS19330 4168067..4168543 + 477 WP_006386993.1 bacterioferritin -
FOC83_RS19335 4168628..4169314 - 687 WP_006386994.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10370.91 Da        Isoelectric Point: 9.0854

>T159904 WP_006386989.1 NZ_CP054571:4164968-4165246 [Achromobacter xylosoxidans]
MLDVSWLQTAADDLAGIISYIAERSPQAARDLRQRIDNAVLSLARHPCRYRAGRVSGTRECVVHPNYVVVYRVTALAIEV
VNIVHARREYPP

Download         Length: 279 bp

>T159904 NZ_CP070170:c498890-498426 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTCGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7729.62 Da        Isoelectric Point: 4.5026

>AT159904 WP_024067400.1 NZ_CP054571:4164692-4164898 [Achromobacter xylosoxidans]
MGPIPSSILSEFETEEQAVSYDRWFRAKVQASLDDPRPAVSHQRVMARIDAIIETACRRQLDPQDGEN

Download         Length: 207 bp

>AT159904 NZ_CP070170:c499225-498890 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTC
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6FFH4

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6FFH2

References