Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 2670041..2670605 Replicon chromosome
Accession NZ_CP054571
Organism Achromobacter xylosoxidans strain FDAARGOS_789

Toxin (Protein)


Gene name relE Uniprot ID A0A0D6IHV7
Locus tag FOC83_RS12310 Protein ID WP_020926667.1
Coordinates 2670041..2670322 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D6IHW1
Locus tag FOC83_RS12315 Protein ID WP_020926666.1
Coordinates 2670309..2670605 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC83_RS12285 2665073..2665576 - 504 WP_006386642.1 flavin reductase family protein -
FOC83_RS12290 2665599..2666612 - 1014 WP_024070172.1 LLM class flavin-dependent oxidoreductase -
FOC83_RS12295 2666734..2667567 + 834 WP_024070173.1 IclR family transcriptional regulator -
FOC83_RS12300 2667803..2668858 + 1056 WP_054442897.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
FOC83_RS12305 2668855..2669991 + 1137 WP_024070175.1 tRNA guanosine(34) transglycosylase Tgt -
FOC83_RS12310 2670041..2670322 - 282 WP_020926667.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOC83_RS12315 2670309..2670605 - 297 WP_020926666.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FOC83_RS12320 2670977..2671321 + 345 WP_006386647.1 preprotein translocase subunit YajC -
FOC83_RS12325 2671437..2673317 + 1881 WP_006386648.1 protein translocase subunit SecD -
FOC83_RS12330 2673369..2674304 + 936 WP_006386649.1 protein translocase subunit SecF -
FOC83_RS12335 2674474..2674842 + 369 WP_006386650.1 type II toxin-antitoxin system RelE/ParE family toxin -
FOC83_RS12340 2674839..2675150 + 312 WP_006386651.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-52)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10262.77 Da        Isoelectric Point: 7.0080

>T159903 WP_020926667.1 NZ_CP054571:c2670322-2670041 [Achromobacter xylosoxidans]
VPAVEWSSAARADLLAIVDYISDDNPDAAQRLKDDIETKAAQLPARPALYRPGRIAGTREMVVRANYIIVYAADALAVRI
LRILHAAQQWPPQ

Download         Length: 282 bp

>T159903 NZ_CP070170:80565-80672 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10717.24 Da        Isoelectric Point: 7.3208

>AT159903 WP_020926666.1 NZ_CP054571:c2670605-2670309 [Achromobacter xylosoxidans]
MPQTSMLHVRVDDKLKADATEKLAEFGLTISDAVRILLTRVAKEGGLPAGLTTDAQAHDAWFRAKVQEALADTGPAVPHQ
QVMDEAQALIDRKRRARS

Download         Length: 297 bp

>AT159903 NZ_CP070170:c80517-80451 [Escherichia coli]
GGTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6IHV7

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6IHW1

References