Detailed information of TA system TA159901

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 6779559..6780153
• Replicon: chromosome
• Accession: NZ_CP054569
• Organism: Achromobacter denitrificans strain FDAARGOS_787

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FOC81_RS31785
• Protein ID: WP_102774659.1
• Coordinates: 6779971..6780153 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FOC81_RS31780
• Protein ID: WP_174717438.1
• Coordinates: 6779559..6779948 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC81_RS31735	6774925..6775074	+	150	WP_174717431.1	hypothetical protein	-
FOC81_RS31740	6775067..6775366	+	300	WP_174717432.1	hypothetical protein	-
FOC81_RS31745	6775363..6775845	+	483	WP_174717433.1	DUF1364 family protein	-
FOC81_RS31750	6775842..6776822	+	981	WP_174717434.1	helix-turn-helix domain-containing protein	-
FOC81_RS31755	6777022..6777435	+	414	WP_174717603.1	hypothetical protein	-
FOC81_RS31760	6777435..6778088	+	654	WP_174717435.1	hypothetical protein	-
FOC81_RS31765	6778296..6779093	+	798	WP_174717436.1	hypothetical protein	-
FOC81_RS31770	6779178..6779369	+	192	WP_174717437.1	hypothetical protein	-
FOC81_RS31780	6779559..6779948	-	390	WP_174717438.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FOC81_RS31785	6779971..6780153	-	183	WP_102774659.1	type II toxin-antitoxin system HicA family toxin	Toxin
FOC81_RS31790	6780314..6780628	+	315	WP_174717439.1	hypothetical protein	-
FOC81_RS31795	6780628..6781008	+	381	WP_174717440.1	HNH endonuclease	-
FOC81_RS31800	6781217..6781699	+	483	WP_174717441.1	phage terminase small subunit P27 family	-
FOC81_RS31805	6781703..6783421	+	1719	WP_174717442.1	terminase large subunit	-
FOC81_RS31810	6783421..6784647	+	1227	WP_174717443.1	phage portal protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	6762284..6816460	54176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6743.85 Da
• Isoelectric Point: 11.0310

>T159901 WP_102774659.1 NZ_CP054569:c6780153-6779971 [Achromobacter denitrificans]
MNSADLIKQLKADGWYHVHTVGSHHQFKHPTKPGKVTVPHPKKDLPIATQRSILKQAGLR

Nucleotide

• Length: 183 bp

>T159901 NZ_CP070169:4810120-4810530 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14225.92 Da
• Isoelectric Point: 4.6402

>AT159901 WP_174717438.1 NZ_CP054569:c6779948-6779559 [Achromobacter denitrificans]
MLYPIHVSKDEGSAYGASFPDFPGCFTGADELRDLPRAAQEAVEAHFHGETSAIPAPSTPEAWANHEDFQGGYWMMVEID
LSKVNAKAVRLNISLPENLVYRIDEEAKARRLSRSAFLAMAAEHEMAST

Nucleotide

• Length: 390 bp

>AT159901 NZ_CP070169:4809873-4810139 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA