Detailed information of TA system TA159900

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 2554342..2555003
• Replicon: chromosome
• Accession: NZ_CP054569
• Organism: Achromobacter denitrificans strain FDAARGOS_787

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A3R9GKR9
• Locus tag: FOC81_RS12105
• Protein ID: WP_062682299.1
• Coordinates: 2554342..2554755 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FOC81_RS12110
• Protein ID: WP_088148885.1
• Coordinates: 2554752..2555003 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC81_RS12080	2549680..2550279	-	600	WP_062682301.1	C40 family peptidase	-
FOC81_RS12085	2550613..2552109	+	1497	WP_062682325.1	AMP nucleosidase	-
FOC81_RS12090	2552340..2553824	+	1485	WP_062682324.1	amino acid permease	-
FOC81_RS12095	2553868..2554035	-	168	WP_174716328.1	hypothetical protein	-
FOC81_RS12100	2554127..2554321	-	195	WP_140419994.1	hypothetical protein	-
FOC81_RS12105	2554342..2554755	-	414	WP_062682299.1	type II toxin-antitoxin system VapC family toxin	Toxin
FOC81_RS12110	2554752..2555003	-	252	WP_088148885.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FOC81_RS12115	2555072..2555452	+	381	WP_125284736.1	hypothetical protein	-
FOC81_RS12120	2555509..2556438	-	930	WP_088148891.1	YicC family protein	-
FOC81_RS12125	2556640..2557359	+	720	WP_172600300.1	ribonuclease PH	-
FOC81_RS12130	2557668..2559065	+	1398	WP_088148890.1	aldehyde dehydrogenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-64)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15466.80 Da
• Isoelectric Point: 5.2418

>T159900 WP_062682299.1 NZ_CP054569:c2554755-2554342 [Achromobacter denitrificans]
MSYLVDTNVLSELRRKQPDGNVVRWLEQRPATTLFLSALTMGELRKGIELMPEGERKRSYLDWLEVELPRFFSGRVLAID
EPVADCWGRLVAQAGRALPAIDSLLAATALAHGLTLVTRNERDFQHPGLDVINPWEV

Nucleotide

• Length: 414 bp

>T159900 NZ_CP070169:4326379-4326747 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9070.20 Da
• Isoelectric Point: 5.0760

>AT159900 WP_088148885.1 NZ_CP054569:c2555003-2554752 [Achromobacter denitrificans]
MHVWQMQEAKSRLSEVVKAAGTQGPQEITVHGRSVAVVLSRADFDKLSGTGESLVAFMRRSPLAGDEDLAFPRDDSLTRE
EGL

Nucleotide

• Length: 252 bp

>AT159900 NZ_CP070169:4326161-4326382 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A3R9GKR9