Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 2671382..2672024 Replicon chromosome
Accession NZ_CP054568
Organism Bacillus thuringiensis strain FDAARGOS_791

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag FOC85_RS14180 Protein ID WP_000635963.1
Coordinates 2671674..2672024 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag FOC85_RS14175 Protein ID WP_000004570.1
Coordinates 2671382..2671669 (+) Length 96 a.a.

Genomic Context


FOC85_RS14150FOC85_RS14160FOC85_RS14165FOC85_RS14170FOC85_RS14175FOC85_RS14180FOC85_RS14185FOC85_RS14195FOC85_RS14155FOC85_RS14190
Location: 2666698..2667660 (963 bp)
Type: Others
Protein ID: WP_000961158.1
Location: 2668318..2668677 (360 bp)
Type: Others
Protein ID: WP_000635040.1
Location: 2668834..2669784 (951 bp)
Type: Others
Protein ID: WP_025388382.1
Location: 2669903..2671072 (1170 bp)
Type: Others
Protein ID: WP_000390600.1
Location: 2671382..2671669 (288 bp)
Type: Antitoxin
Protein ID: WP_000004570.1
Location: 2671674..2672024 (351 bp)
Type: Toxin
Protein ID: WP_000635963.1
Location: 2672092..2674260 (2169 bp)
Type: Others
Protein ID: WP_000426225.1
Location: 2674630..2675088 (459 bp)
Type: Others
Protein ID: WP_000344244.1
Location: 2667653..2668225 (573 bp)
Type: Others
Protein ID: WP_000906926.1
Location: 2674318..2674434 (117 bp)
Type: Others
Protein ID: WP_001143642.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FOC85_RS141502666698..2667660+963WP_000961158.1UV DNA damage repair endonuclease UvsE-
FOC85_RS141552667653..2668225-573WP_000906926.1rhomboid family intramembrane serine protease-
FOC85_RS141602668318..2668677+360WP_000635040.1holo-ACP synthase-
FOC85_RS141652668834..2669784+951WP_025388382.1outer membrane lipoprotein carrier protein LolA-
FOC85_RS141702669903..2671072+1170WP_000390600.1alanine racemase-
FOC85_RS141752671382..2671669+288WP_000004570.1antitoxin EndoAIAntitoxin
FOC85_RS141802671674..2672024+351WP_000635963.1type II toxin-antitoxin system endoribonuclease NdoAToxin
FOC85_RS141852672092..2674260+2169WP_000426225.1RNA-binding transcriptional accessory protein-
FOC85_RS141902674318..2674434-117WP_001143642.1cortex morphogenetic protein CmpA-
FOC85_RS141952674630..2675088+459WP_000344244.1SprT family protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-113)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T159897 WP_000635963.1 NZ_CP054568:2671674-2672024 [Bacillus thuringiensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T159897 NZ_CP070169:c3446030-3445746 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCTGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT159897 WP_000004570.1 NZ_CP054568:2671382-2671669 [Bacillus thuringiensis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT159897 NZ_CP070169:c3446262-3446020 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
PDB4HKE
PDB7BXY


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366FY90

References