Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1577241..1577920 Replicon chromosome
Accession NZ_CP054560
Organism Acinetobacter baumannii strain YC103

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag HUF98_RS07535 Protein ID WP_000838146.1
Coordinates 1577241..1577423 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag HUF98_RS07540 Protein ID WP_000966688.1
Coordinates 1577516..1577920 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUF98_RS07495 (HUF98_07475) 1572352..1572759 + 408 WP_000247950.1 hypothetical protein -
HUF98_RS07500 (HUF98_07480) 1572731..1573099 + 369 WP_002037239.1 hypothetical protein -
HUF98_RS07505 (HUF98_07485) 1573056..1573499 + 444 WP_236753938.1 phage tail terminator-like protein -
HUF98_RS07510 (HUF98_07490) 1573501..1573719 + 219 WP_031380852.1 hypothetical protein -
HUF98_RS07515 (HUF98_07495) 1573815..1574168 + 354 WP_236753936.1 hypothetical protein -
HUF98_RS07520 (HUF98_07500) 1574168..1575316 + 1149 WP_108663972.1 phage tail protein -
HUF98_RS07525 (HUF98_07505) 1575413..1576330 + 918 WP_236754234.1 phage tail tube protein -
HUF98_RS07530 (HUF98_07510) 1576400..1576915 + 516 WP_236754236.1 hypothetical protein -
HUF98_RS07535 (HUF98_07515) 1577241..1577423 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
HUF98_RS07540 (HUF98_07520) 1577516..1577920 + 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HUF98_RS07545 (HUF98_07525) 1578019..1578543 + 525 WP_031977118.1 DUF4468 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1547141..1599826 52685


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T159893 WP_000838146.1 NZ_CP054560:1577241-1577423 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T159893 NZ_CP070169:684518-684620 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT159893 WP_000966688.1 NZ_CP054560:1577516-1577920 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT159893 NZ_CP070169:c684627-684482 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References