Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3925234..3926032 Replicon chromosome
Accession NZ_CP054556
Organism Escherichia coli strain LWY24

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HT750_RS18990 Protein ID WP_174617262.1
Coordinates 3925234..3925611 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1EW42
Locus tag HT750_RS18995 Protein ID WP_032153712.1
Coordinates 3925658..3926032 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HT750_RS18960 3920709..3922166 + 1458 Protein_3702 DUF4092 domain-containing protein -
HT750_RS18965 3922162..3922794 + 633 Protein_3703 type II secretion system protein GspL -
HT750_RS18970 3922796..3923332 + 537 WP_000942785.1 GspM family type II secretion system protein YghD -
HT750_RS18975 3923613..3924455 - 843 WP_040235333.1 DUF4942 domain-containing protein -
HT750_RS18980 3924540..3924737 - 198 WP_032152719.1 DUF957 domain-containing protein -
HT750_RS18985 3924749..3925237 - 489 WP_001774608.1 hypothetical protein -
HT750_RS18990 3925234..3925611 - 378 WP_174617262.1 TA system toxin CbtA family protein Toxin
HT750_RS18995 3925658..3926032 - 375 WP_032153712.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
HT750_RS19000 3926112..3926333 - 222 WP_000692345.1 DUF987 domain-containing protein -
HT750_RS19005 3926402..3926878 - 477 WP_001186715.1 RadC family protein -
HT750_RS19010 3926894..3927379 - 486 WP_032153711.1 antirestriction protein -
HT750_RS19015 3927471..3928289 - 819 WP_174617263.1 DUF945 domain-containing protein -
HT750_RS19020 3928380..3928589 - 210 WP_023155727.1 DUF905 family protein -
HT750_RS19025 3928619..3929296 - 678 WP_023155728.1 hypothetical protein -
HT750_RS19030 3929415..3930299 - 885 WP_024166630.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14222.18 Da        Isoelectric Point: 7.8045

>T159889 WP_174617262.1 NZ_CP054556:c3925611-3925234 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDTVNFLVEKYALIRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T159889 NZ_CP070162:c4349943-4349836 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCAGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13697.51 Da        Isoelectric Point: 6.6240

>AT159889 WP_032153712.1 NZ_CP054556:c3926032-3925658 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT159889 NZ_CP070162:4349991-4350057 [Escherichia coli]
GGTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1EW42

References