Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3816182..3817023 Replicon chromosome
Accession NZ_CP054556
Organism Escherichia coli strain LWY24

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1M0WJM1
Locus tag HT750_RS18450 Protein ID WP_000854822.1
Coordinates 3816640..3817023 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A243ZR83
Locus tag HT750_RS18445 Protein ID WP_071587515.1
Coordinates 3816182..3816550 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HT750_RS18425 3813929..3814747 + 819 WP_174617261.1 DUF945 domain-containing protein -
HT750_RS18430 3814839..3815321 + 483 WP_000206657.1 antirestriction protein -
HT750_RS18435 3815336..3815812 + 477 WP_001186740.1 RadC family protein -
HT750_RS18440 3815881..3816102 + 222 WP_000692312.1 DUF987 domain-containing protein -
HT750_RS18445 3816182..3816550 + 369 WP_071587515.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HT750_RS18450 3816640..3817023 + 384 WP_000854822.1 type IV toxin-antitoxin system toxin CbtA Toxin
HT750_RS18455 3817014..3817502 + 489 WP_001177592.1 hypothetical protein -
HT750_RS18460 3817514..3817711 + 198 WP_000839263.1 DUF957 domain-containing protein -
HT750_RS18465 3817808..3818653 + 846 WP_001280435.1 DUF4942 domain-containing protein -
HT750_RS18475 3818952..3819458 + 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
HT750_RS18480 3819537..3821378 - 1842 WP_000437371.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14295.32 Da        Isoelectric Point: 8.2830

>T159887 WP_000854822.1 NZ_CP054556:3816640-3817023 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHQESKRCN

Download         Length: 384 bp

>T159887 NZ_CP070162:c3442113-3441778 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13631.41 Da        Isoelectric Point: 6.6244

>AT159887 WP_071587515.1 NZ_CP054556:3816182-3816550 [Escherichia coli]
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLTDRAGIRGRFSDADANHLDQAFPLLMKQLELMLTSS
ELNPHRQNTVTLYVKGLTCHADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT159887 NZ_CP070162:c3442361-3442113 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M0WJM1

Antitoxin

Source ID Structure
AlphaFold DB A0A243ZR83

References