Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 1199423..1199988 Replicon chromosome
Accession NZ_CP054528
Organism Bifidobacterium longum subsp. infantis strain NLS

Toxin (Protein)


Gene name relE Uniprot ID A0A0M4LG91
Locus tag HUE59_RS05115 Protein ID WP_060620320.1
Coordinates 1199423..1199713 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7D5CUA8
Locus tag HUE59_RS05120 Protein ID WP_032743427.1
Coordinates 1199710..1199988 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUE59_RS05095 (HUE59_05105) 1194632..1195198 + 567 WP_032743433.1 DUF3566 domain-containing protein -
HUE59_RS05100 (HUE59_05110) 1195844..1197265 + 1422 WP_032743432.1 ATP-binding protein -
HUE59_RS05105 (HUE59_05115) 1197326..1197550 - 225 WP_032743431.1 substrate-binding domain-containing protein -
HUE59_RS05110 (HUE59_05120) 1197699..1199045 - 1347 WP_032743429.1 NADP-specific glutamate dehydrogenase -
HUE59_RS05115 (HUE59_05125) 1199423..1199713 - 291 WP_060620320.1 type II toxin-antitoxin system YafQ family toxin Toxin
HUE59_RS05120 (HUE59_05130) 1199710..1199988 - 279 WP_032743427.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUE59_RS11530 1200461..1200688 - 228 WP_212105774.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
HUE59_RS05130 (HUE59_05140) 1200791..1201435 + 645 WP_032743426.1 hypothetical protein -
HUE59_RS05135 (HUE59_05145) 1201857..1202048 - 192 WP_032743423.1 hypothetical protein -
HUE59_RS05150 (HUE59_05160) 1203523..1204785 - 1263 WP_032743422.1 metallophosphoesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1197326..1211468 14142


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(6-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-70)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10839.54 Da        Isoelectric Point: 9.9591

>T159861 WP_060620320.1 NZ_CP054528:c1199713-1199423 [Bifidobacterium longum subsp. infantis]
MSGIQYTVKTTSRFRKDFKLARRRGLDAGLFKQVVSILSEGGTLPDRYHDHALTGNMTGFRECHITPDLLLVYLIEKDVL
VLTLTRTGTHSDLFGK

Download         Length: 291 bp

>T159861 NZ_CP070158:c396320-395952 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10274.69 Da        Isoelectric Point: 5.1231

>AT159861 WP_032743427.1 NZ_CP054528:c1199988-1199710 [Bifidobacterium longum subsp. infantis]
MSGTTTTVNVRMNAELKKQAEELFEELGMNLTTAVNIFIRQSLRQGGIPFNVSLDEPNRETVSAMLEAKRIARDGNVKGY
RDLNALFKDLDA

Download         Length: 279 bp

>AT159861 NZ_CP070158:c396538-396317 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4LG91

Antitoxin

Source ID Structure
AlphaFold DB A0A7D5CUA8

References