Detailed information of TA system TA159860

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 562826..563315
• Replicon: chromosome
• Accession: NZ_CP054528
• Organism: Bifidobacterium longum subsp. infantis strain NLS

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HUE59_RS02505
• Protein ID: WP_229773994.1
• Coordinates: 562826..563053 (-)
• Length: 76 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A4V2N072
• Locus tag: HUE59_RS02510
• Protein ID: WP_032744823.1
• Coordinates: 563079..563315 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUE59_RS02490 (HUE59_02490)	560049..560771	-	723	WP_032744819.1	hypothetical protein	-
HUE59_RS02495 (HUE59_02495)	560836..561792	-	957	WP_032744820.1	A/G-specific adenine glycosylase	-
HUE59_RS02500 (HUE59_02500)	561813..562475	+	663	WP_136527151.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
HUE59_RS02505 (HUE59_02505)	562826..563053	-	228	WP_229773994.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HUE59_RS02510 (HUE59_02510)	563079..563315	-	237	WP_032744823.1	ribbon-helix-helix domain-containing protein	Antitoxin
HUE59_RS02515 (HUE59_02515)	563898..564611	-	714	WP_080714860.1	4'-phosphopantetheinyl transferase superfamily protein	-
HUE59_RS02520 (HUE59_02520)	564622..565947	-	1326	WP_230581269.1	MFS transporter	-
HUE59_RS02525 (HUE59_02525)	565974..567161	-	1188	WP_032744825.1	carboxylate--amine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	562826..572159	9333

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-72)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 8653.22 Da
• Isoelectric Point: 10.1818

>T159860 WP_229773994.1 NZ_CP054528:c563053-562826 [Bifidobacterium longum subsp. infantis]
MKKLDRNVAKRIIAKLREISQLEDPRSTGKALAGNLAGLWRYRVGDYRIVCDIEDEVLLILVIDVAHRSKVYKRC

Nucleotide

• Length: 228 bp

>T159860 NZ_CP070158:c32072-31731 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCTATAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGCTACTTAC
ACGCCTGCTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTGTGATGAAACCGTTATACAGGAACATATCG
ATGCCGGTATTACGCTGGCTGATGCCGTTAATTTTCTGGTGGAAAAATACGGACTGGTTCGTATCGACAGGAATGGATTT
GTCTGGCAGGAACAATCACCTTATCTTCGGGCCGTTGATATTCTGCGAGCGCGGCAGGCAACTGGCTTATTGCGACAAAG
CCGTAACAACGCAATACGTTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8928.15 Da
• Isoelectric Point: 4.2821

>AT159860 WP_032744823.1 NZ_CP054528:c563315-563079 [Bifidobacterium longum subsp. infantis]
MATVTAALRMPVELAARYDCLAKATGRTKTFYMNEALTESIDRFEYEYGIMKKVEDWRAGRLETVTLDELEESLGLED

Nucleotide

• Length: 237 bp

>AT159860 NZ_CP070158:c32410-32093 [Klebsiella pneumoniae]
ATGAGCAACATTACATGGGGCCTGCAGCGGGATACCACGCCGCGTCTGGGAGCCCGTCTGGTACAGGAGGGGAACCAACT
GCATTATCTGGCTGACCGGGCCAGTATGACCGGTAAATTCAGTGACGCCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAATCGATGCTGATCACTGGTGAAATGAATCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGCCGTTTACCCCATCCAACGATAA

Structures

Antitoxin

• AlphaFold DB: A0A4V2N072