Detailed information of TA system TA159857

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2721435..2722000
• Replicon: chromosome
• Accession: NZ_CP054527
• Organism: Bifidobacterium longum subsp. infantis strain BB-02

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HUE60_RS12360
• Protein ID: WP_234895543.1
• Coordinates: 2721435..2721650 (-)
• Length: 72 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B7GSH1
• Locus tag: HUE60_RS12365
• Protein ID: WP_012576473.1
• Coordinates: 2721722..2722000 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUE60_RS12340 (HUE60_12330)	2716644..2717210	+	567	WP_032743433.1	DUF3566 domain-containing protein	-
HUE60_RS12345 (HUE60_12335)	2717856..2719277	+	1422	WP_071477783.1	ATP-binding protein	-
HUE60_RS12350 (HUE60_12340)	2719338..2719562	-	225	WP_060620314.1	substrate-binding domain-containing protein	-
HUE60_RS12355 (HUE60_12345)	2719713..2721059	-	1347	WP_193641811.1	NADP-specific glutamate dehydrogenase	-
HUE60_RS12360 (HUE60_12350)	2721435..2721650	-	216	WP_234895543.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HUE60_RS12365 (HUE60_12355)	2721722..2722000	-	279	WP_012576473.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HUE60_RS12370 (HUE60_12360)	2722474..2722590	-	117	Protein_2418	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
HUE60_RS12375 (HUE60_12365)	2722804..2723448	+	645	WP_212104116.1	hypothetical protein	-
HUE60_RS12380 (HUE60_12370)	2723870..2724424	-	555	WP_187324443.1	hypothetical protein	-
HUE60_RS12395 (HUE60_12385)	2725539..2726801	-	1263	WP_212104118.1	metallophosphoesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2719338..2733485	14147

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-70)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-70)

Sequences

Toxin

Protein

• Length: 72 a.a.
• Molecular weight: 7872.07 Da
• Isoelectric Point: 6.0467

>T159857 WP_234895543.1 NZ_CP054527:c2721650-2721435 [Bifidobacterium longum subsp. infantis]
MDAGLFKQVVSILSEGGTLPDRYHDHALTGNMTGFRECHITPDLLLVYLIEKDVLVLTLTRTGTHSDLFGK

Nucleotide

• Length: 216 bp

>T159857 NZ_CP070157:c4908212-4907826 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10202.63 Da
• Isoelectric Point: 6.3216

>AT159857 WP_012576473.1 NZ_CP054527:c2722000-2721722 [Bifidobacterium longum subsp. infantis]
MSGTTTTVNVRMNAELKKQAEELFGELGMNLTTAVNIFIRQSLRQGGIPFNVSLDEPNRETVSAMLEAKRIARDGNVKGY
RDLNALFKDLDA

Nucleotide

• Length: 279 bp

>AT159857 NZ_CP070157:c4907836-4907507 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0A8MHE5