Detailed information of TA system TA159856

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 2126070..2126559
• Replicon: chromosome
• Accession: NZ_CP054527
• Organism: Bifidobacterium longum subsp. infantis strain BB-02

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HUE60_RS09910
• Protein ID: WP_229773994.1
• Coordinates: 2126070..2126297 (-)
• Length: 76 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A4V2N072
• Locus tag: HUE60_RS09915
• Protein ID: WP_032744823.1
• Coordinates: 2126323..2126559 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUE60_RS09895 (HUE60_09870)	2123293..2124015	-	723	WP_060620046.1	hypothetical protein	-
HUE60_RS09900 (HUE60_09875)	2124080..2125036	-	957	WP_212105731.1	A/G-specific adenine glycosylase	-
HUE60_RS09905 (HUE60_09880)	2125057..2125719	+	663	WP_003828427.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
HUE60_RS09910 (HUE60_09885)	2126070..2126297	-	228	WP_229773994.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HUE60_RS09915 (HUE60_09890)	2126323..2126559	-	237	WP_032744823.1	ribbon-helix-helix domain-containing protein	Antitoxin
HUE60_RS09920 (HUE60_09905)	2127866..2129191	-	1326	WP_234932960.1	MFS transporter	-
HUE60_RS09925 (HUE60_09910)	2129219..2130406	-	1188	WP_174774172.1	carboxylate--amine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-72)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 8653.22 Da
• Isoelectric Point: 10.1818

>T159856 WP_229773994.1 NZ_CP054527:c2126297-2126070 [Bifidobacterium longum subsp. infantis]
MKKLDRNVAKRIIAKLREISQLEDPRSTGKALAGNLAGLWRYRVGDYRIVCDIEDEVLLILVIDVAHRSKVYKRC

Nucleotide

• Length: 228 bp

>T159856 NZ_CP070157:c4505254-4505036 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8928.15 Da
• Isoelectric Point: 4.2821

>AT159856 WP_032744823.1 NZ_CP054527:c2126559-2126323 [Bifidobacterium longum subsp. infantis]
MATVTAALRMPVELAARYDCLAKATGRTKTFYMNEALTESIDRFEYEYGIMKKVEDWRAGRLETVTLDELEESLGLED

Nucleotide

• Length: 237 bp

>AT159856 NZ_CP070157:c4505654-4505280 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A4V2N072