Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 2320509..2321362 Replicon chromosome
Accession NZ_CP054526
Organism Bifidobacterium longum subsp. infantis strain PI_002

Toxin (Protein)


Gene name relE Uniprot ID A0A7D5BU34
Locus tag HUE61_RS10075 Protein ID WP_032745209.1
Coordinates 2320871..2321362 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q8G4I4
Locus tag HUE61_RS10070 Protein ID WP_011068030.1
Coordinates 2320509..2320871 (+) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUE61_RS10065 (HUE61_10095) 2317664..2320363 + 2700 WP_032745210.1 aconitate hydratase AcnA -
HUE61_RS10070 (HUE61_10100) 2320509..2320871 + 363 WP_011068030.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUE61_RS10075 (HUE61_10105) 2320871..2321362 + 492 WP_032745209.1 PIN domain-containing protein Toxin
HUE61_RS10080 (HUE61_10110) 2321423..2323527 - 2105 Protein_1965 DUF262 domain-containing protein -
HUE61_RS10085 (HUE61_10115) 2323616..2324257 - 642 WP_032745208.1 GNAT family N-acetyltransferase -
HUE61_RS10090 (HUE61_10120) 2324298..2324438 - 141 Protein_1967 LuxR C-terminal-related transcriptional regulator -
HUE61_RS10095 (HUE61_10125) 2324607..2325509 + 903 WP_032745207.1 Bax inhibitor-1/YccA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-141)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-53)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18298.86 Da        Isoelectric Point: 4.5590

>T159851 WP_032745209.1 NZ_CP054526:2320871-2321362 [Bifidobacterium longum subsp. infantis]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNVTLLCASLSLKDIAYLSSSAIRRECKPNESEVENFTRGF
LSSRVPWRCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCRTPAEIVA
ALE

Download         Length: 492 bp

>T159851 NZ_CP070157:3483374-3483481 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 14004.05 Da        Isoelectric Point: 5.0733

>AT159851 WP_011068030.1 NZ_CP054526:2320509-2320871 [Bifidobacterium longum subsp. infantis]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDTYYNMKRAD

Download         Length: 363 bp

>AT159851 NZ_CP070157:c3483325-3483262 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D5BU34

Antitoxin

Source ID Structure
AlphaFold DB A0A1S2W1N3

References