Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 2231656..2232239 Replicon chromosome
Accession NZ_CP054526
Organism Bifidobacterium longum subsp. infantis strain PI_002

Toxin (Protein)


Gene name PumA Uniprot ID A0A1S2VZ23
Locus tag HUE61_RS09720 Protein ID WP_032745284.1
Coordinates 2231937..2232239 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID I3AVV5
Locus tag HUE61_RS09715 Protein ID WP_007057517.1
Coordinates 2231656..2231940 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUE61_RS09690 (HUE61_09720) 2227800..2228168 - 369 WP_155270629.1 hypothetical protein -
HUE61_RS09695 (HUE61_09725) 2228162..2229244 + 1083 Protein_1888 transposase -
HUE61_RS09700 (HUE61_09730) 2229342..2230250 + 909 WP_032744304.1 ABC transporter ATP-binding protein -
HUE61_RS09705 (HUE61_09735) 2230247..2230978 + 732 WP_032744305.1 ABC transporter permease -
HUE61_RS09710 (HUE61_09740) 2230996..2231547 - 552 Protein_1891 IS30 family transposase -
HUE61_RS09715 (HUE61_09745) 2231656..2231940 - 285 WP_007057517.1 putative addiction module antidote protein Antitoxin
HUE61_RS09720 (HUE61_09750) 2231937..2232239 - 303 WP_032745284.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUE61_RS09725 (HUE61_09755) 2232277..2232711 - 435 WP_230581286.1 DUF1922 domain-containing protein -
HUE61_RS09730 (HUE61_09760) 2232732..2233220 + 489 WP_032745281.1 D-aminoacyl-tRNA deacylase -
HUE61_RS09735 (HUE61_09765) 2233381..2236500 + 3120 WP_136527129.1 alpha-mannosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2230996..2231451 455


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(9-92)

Antitoxin

Uncharacterized protein HI1420

(3-92)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11350.08 Da        Isoelectric Point: 10.4626

>T159850 WP_032745284.1 NZ_CP054526:c2232239-2231937 [Bifidobacterium longum subsp. infantis]
IKQSAEYRKWFKKLRDHKAKAAIQARLDACKLAGRPFGDIKPVGGPVSEMRFHTGAGYRVYFAMQGNVLMLLLAGGDKST
QQTDIRQAHDILNDYKEQRQ

Download         Length: 303 bp

>T159850 NZ_CP070157:3482890-3482997 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10158.37 Da        Isoelectric Point: 4.3707

>AT159850 WP_007057517.1 NZ_CP054526:c2231940-2231656 [Bifidobacterium longum subsp. infantis]
MSTEFTDYDTSEYLENEQDIIAYLNAIAEYDDPALMQAALGNVAKARGMTQIAKDAGVGRESLYKSLSKDGNPSFQTIAK
VIHALGGRLTIQAA

Download         Length: 285 bp

>AT159850 NZ_CP070157:c3482832-3482778 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S2VZ23

Antitoxin

Source ID Structure
AlphaFold DB I3AVV5

References