Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 1205695..1206260 Replicon chromosome
Accession NZ_CP054526
Organism Bifidobacterium longum subsp. infantis strain PI_002

Toxin (Protein)


Gene name relE Uniprot ID A0A0M4LG91
Locus tag HUE61_RS05165 Protein ID WP_060620320.1
Coordinates 1205695..1205985 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7D5CUA8
Locus tag HUE61_RS05170 Protein ID WP_032743427.1
Coordinates 1205982..1206260 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUE61_RS05145 (HUE61_05160) 1200904..1201470 + 567 WP_032743433.1 DUF3566 domain-containing protein -
HUE61_RS05150 (HUE61_05165) 1202116..1203537 + 1422 WP_032743432.1 ATP-binding protein -
HUE61_RS05155 (HUE61_05170) 1203598..1203822 - 225 WP_032743431.1 substrate-binding domain-containing protein -
HUE61_RS05160 (HUE61_05175) 1203971..1205317 - 1347 WP_032743429.1 NADP-specific glutamate dehydrogenase -
HUE61_RS05165 (HUE61_05180) 1205695..1205985 - 291 WP_060620320.1 type II toxin-antitoxin system YafQ family toxin Toxin
HUE61_RS05170 (HUE61_05185) 1205982..1206260 - 279 WP_032743427.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUE61_RS11615 1206733..1206960 - 228 WP_212105774.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
HUE61_RS05180 (HUE61_05195) 1207063..1207707 + 645 WP_032743426.1 hypothetical protein -
HUE61_RS05185 (HUE61_05200) 1208129..1208320 - 192 WP_032743423.1 hypothetical protein -
HUE61_RS05200 (HUE61_05215) 1209795..1211057 - 1263 WP_032743422.1 metallophosphoesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1203598..1217740 14142


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(6-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-70)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10839.54 Da        Isoelectric Point: 9.9591

>T159849 WP_060620320.1 NZ_CP054526:c1205985-1205695 [Bifidobacterium longum subsp. infantis]
MSGIQYTVKTTSRFRKDFKLARRRGLDAGLFKQVVSILSEGGTLPDRYHDHALTGNMTGFRECHITPDLLLVYLIEKDVL
VLTLTRTGTHSDLFGK

Download         Length: 291 bp

>T159849 NZ_CP070157:3427205-3427390 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10274.69 Da        Isoelectric Point: 5.1231

>AT159849 WP_032743427.1 NZ_CP054526:c1206260-1205982 [Bifidobacterium longum subsp. infantis]
MSGTTTTVNVRMNAELKKQAEELFEELGMNLTTAVNIFIRQSLRQGGIPFNVSLDEPNRETVSAMLEAKRIARDGNVKGY
RDLNALFKDLDA

Download         Length: 279 bp

>AT159849 NZ_CP070157:3427407-3427817 [Escherichia coli]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGTGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCGAAAAGGTTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCAGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4LG91

Antitoxin

Source ID Structure
AlphaFold DB A0A7D5CUA8

References