Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 2130282..2131135 Replicon chromosome
Accession NZ_CP054525
Organism Bifidobacterium longum subsp. infantis strain PI_003

Toxin (Protein)


Gene name relE Uniprot ID A0A7D5BU34
Locus tag HUE62_RS09635 Protein ID WP_032745209.1
Coordinates 2130282..2130773 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q8G4I4
Locus tag HUE62_RS09640 Protein ID WP_011068030.1
Coordinates 2130773..2131135 (-) Length 121 a.a.

Genomic Context


HUE62_RS09620HUE62_RS09625HUE62_RS09630HUE62_RS09615HUE62_RS09635HUE62_RS09640HUE62_RS09645
Location: 2127206..2127346 (141 bp)
Type: Others
Protein ID: Protein_1870
Location: 2127387..2128028 (642 bp)
Type: Others
Protein ID: WP_032745208.1
Location: 2128117..2130221 (2105 bp)
Type: Others
Protein ID: Protein_1872
Location: 2126135..2127037 (903 bp)
Type: Others
Protein ID: WP_032745207.1
Location: 2130282..2130773 (492 bp)
Type: Toxin
Protein ID: WP_032745209.1
Location: 2130773..2131135 (363 bp)
Type: Antitoxin
Protein ID: WP_011068030.1
Location: 2131281..2133980 (2700 bp)
Type: Others
Protein ID: WP_032745210.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HUE62_RS09615 (HUE62_09550)2126135..2127037-903WP_032745207.1Bax inhibitor-1/YccA family protein-
HUE62_RS09620 (HUE62_09555)2127206..2127346+141Protein_1870LuxR C-terminal-related transcriptional regulator-
HUE62_RS09625 (HUE62_09560)2127387..2128028+642WP_032745208.1GNAT family N-acetyltransferase-
HUE62_RS09630 (HUE62_09565)2128117..2130221+2105Protein_1872DUF262 domain-containing protein-
HUE62_RS09635 (HUE62_09570)2130282..2130773-492WP_032745209.1PIN domain-containing proteinToxin
HUE62_RS09640 (HUE62_09575)2130773..2131135-363WP_011068030.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
HUE62_RS09645 (HUE62_09580)2131281..2133980-2700WP_032745210.1aconitate hydratase AcnA-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-141)

Antitoxin

(6-53)


Sequences


Toxin        


Download         Length: 164 a.a.        Molecular weight: 18298.86 Da        Isoelectric Point: 4.5590

>T159844 WP_032745209.1 NZ_CP054525:c2130773-2130282 [Bifidobacterium longum subsp. infantis]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNVTLLCASLSLKDIAYLSSSAIRRECKPNESEVENFTRGF
LSSRVPWRCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCRTPAEIVA
ALE

Download         Length: 492 bp

>T159844 NZ_CP070157:2283358-2283735 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGTACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 14004.05 Da        Isoelectric Point: 5.0733

>AT159844 WP_011068030.1 NZ_CP054525:c2131135-2130773 [Bifidobacterium longum subsp. infantis]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDTYYNMKRAD

Download         Length: 363 bp

>AT159844 NZ_CP070157:2282900-2283268 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTAACAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A7D5BU34


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1S2W1N3

References