Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 633467..634032 Replicon chromosome
Accession NZ_CP054525
Organism Bifidobacterium longum subsp. infantis strain PI_003

Toxin (Protein)


Gene name relE Uniprot ID A0A0M4LG91
Locus tag HUE62_RS02955 Protein ID WP_060620320.1
Coordinates 633742..634032 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7D5CUA8
Locus tag HUE62_RS02950 Protein ID WP_032743427.1
Coordinates 633467..633745 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUE62_RS02920 (HUE62_02905) 628670..629932 + 1263 WP_032743422.1 metallophosphoesterase -
HUE62_RS02935 (HUE62_02920) 631407..631598 + 192 WP_032743423.1 hypothetical protein -
HUE62_RS02940 (HUE62_02925) 632020..632664 - 645 WP_032743426.1 hypothetical protein -
HUE62_RS11645 632767..632994 + 228 WP_212105774.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
HUE62_RS02950 (HUE62_02935) 633467..633745 + 279 WP_032743427.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUE62_RS02955 (HUE62_02940) 633742..634032 + 291 WP_060620320.1 type II toxin-antitoxin system YafQ family toxin Toxin
HUE62_RS02960 (HUE62_02945) 634410..635756 + 1347 WP_032743429.1 NADP-specific glutamate dehydrogenase -
HUE62_RS02965 (HUE62_02950) 635905..636129 + 225 WP_032743431.1 substrate-binding domain-containing protein -
HUE62_RS02970 (HUE62_02955) 636190..637611 - 1422 WP_032743432.1 ATP-binding protein -
HUE62_RS02975 (HUE62_02960) 638257..638823 - 567 WP_032743433.1 DUF3566 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 623562..637611 14049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(6-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-70)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10839.54 Da        Isoelectric Point: 9.9591

>T159840 WP_060620320.1 NZ_CP054525:633742-634032 [Bifidobacterium longum subsp. infantis]
MSGIQYTVKTTSRFRKDFKLARRRGLDAGLFKQVVSILSEGGTLPDRYHDHALTGNMTGFRECHITPDLLLVYLIEKDVL
VLTLTRTGTHSDLFGK

Download         Length: 291 bp

>T159840 NZ_CP070157:c956968-956865 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10274.69 Da        Isoelectric Point: 5.1231

>AT159840 WP_032743427.1 NZ_CP054525:633467-633745 [Bifidobacterium longum subsp. infantis]
MSGTTTTVNVRMNAELKKQAEELFEELGMNLTTAVNIFIRQSLRQGGIPFNVSLDEPNRETVSAMLEAKRIARDGNVKGY
RDLNALFKDLDA

Download         Length: 279 bp

>AT159840 NZ_CP070157:956827-957098 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGCCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4LG91

Antitoxin

Source ID Structure
AlphaFold DB A0A7D5CUA8

References